Visible-Light-Initiated Difunctionalization of Quinoxalin-2(1H)‑ones with Acyloxy Nitroso Compounds

Herein, a photoinitiated radical relay reaction of quinoxalin-2­(1H)-ones, with acyloxy nitroso compounds as a source of radicals, is described. Although the C–H functionalization of quinoxalin-2­(1H)-ones has been investigated, its difunctionalization, the simultaneous construction of C–C and N–N b...

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Bibliographic Details
Published in:Organic letters 2022-10, Vol.24 (39), p.7118-7122
Main Authors: Gao, Runye, Wang, Fang, Geng, Xiao, Li, Chuan-Ying, Wang, Lei
Format: Article
Language:English
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Summary:Herein, a photoinitiated radical relay reaction of quinoxalin-2­(1H)-ones, with acyloxy nitroso compounds as a source of radicals, is described. Although the C–H functionalization of quinoxalin-2­(1H)-ones has been investigated, its difunctionalization, the simultaneous construction of C–C and N–N bonds directly via the radical relay reaction, has rarely been reported. Moreover, the obtained products underwent sequential reactions to access C7-NO2 of quinoxalin-2­(1H)-ones under mild conditions.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.2c02703