Intravenous thrombolysis for treatment of pediatric acute ischemic stroke: Analysis of 20 years of population-level data in the United States

Background and Aims: Although intravenous thrombolysis (IVT) represents standard-of-care treatment for acute ischemic stroke (AIS) in eligible adult patients, definitive evidence-based guidelines and randomized clinical trial data evaluating its safety and efficacy in the pediatric population remain...

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Bibliographic Details
Published in:International journal of stroke 2023-06, Vol.18 (5), p.555-561
Main Authors: Dicpinigaitis, Alis J, Shapiro, Steven D, Nuoman, Rolla, Kamal, Haris, Overby, Philip, Kaur, Gurmeen, Chong, Ji Y, Fifi, Johanna T, Dangayach, Neha, Miller, Eliza C, Yaghi, Shadi, Al-Mufti, Fawaz
Format: Article
Language:English
Subjects:
Adult
Brain Ischemia - complications
Brain Ischemia - drug therapy
Brain Ischemia - epidemiology
Child
Fibrinolytic Agents - adverse effects
Humans
Intracranial Hemorrhages - complications
Ischemic Stroke - drug therapy
Stroke - drug therapy
Stroke - epidemiology
Stroke - etiology
Thrombolytic Therapy - methods
Treatment Outcome
United States - epidemiology
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Summary:Background and Aims: Although intravenous thrombolysis (IVT) represents standard-of-care treatment for acute ischemic stroke (AIS) in eligible adult patients, definitive evidence-based guidelines and randomized clinical trial data evaluating its safety and efficacy in the pediatric population remain absent from the literature. We aimed to evaluate the utilization and outcomes of IVT for the treatment of pediatric AIS using a large national registry. Methods: Weighted hospitalizations for pediatric (
ISSN:1747-4930
1747-4949
DOI:10.1177/17474930221130911