Decreased Na + /K + pump activity in the erythrocyte membrane due to malondialdehyde in rheumatoid arthritis: an in vivo and in silico study

Apart from demonstrating the interaction behavior of malondialdehyde (MDA) with Na + /K + -ATPase using in silico, the current study aims to investigate the effect of rheumatoid arthritis-related oxidative stress on Na + /K + -ATPase activity that is present in the erythrocyte cell membrane, which i...

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Published in:Canadian journal of physiology and pharmacology 2022-10, Vol.100 (10), p.968-982
Main Authors: Oğul, Yasemin, Gür, Fatma, Gür, Bahri, Cengiz, Mustafa, Sarı, Refik Ali, Kızıltunç, Ahmet
Format: Article
Language:English
Subjects:
Cell membranes
Free radicals
Malondialdehyde
Na+/K+-exchanging ATPase
Oxidative stress
Population studies
Rheumatoid arthritis
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description Apart from demonstrating the interaction behavior of malondialdehyde (MDA) with Na + /K + -ATPase using in silico, the current study aims to investigate the effect of rheumatoid arthritis-related oxidative stress on Na + /K + -ATPase activity that is present in the erythrocyte cell membrane, which is rich in proteins vulnerable to damage from MDA and other free radicals. The target population of this study consists of 28 rheumatoid arthritis patients and 20 healthy volunteers whose MDA levels and Na + /K + -ATPase activity were determined. It was shown that MDA levels of rheumatoid arthritis patients increased ( p 
doi_str_mv 10.1139/cjpp-2022-0171
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The target population of this study consists of 28 rheumatoid arthritis patients and 20 healthy volunteers whose MDA levels and Na + /K + -ATPase activity were determined. It was shown that MDA levels of rheumatoid arthritis patients increased ( p &lt; 0.001) and their Na + /K + -ATPase activity noticeably decreased when compared to those of healthy individuals. Also, according to this in silico modeling, MDA decreased Na + /K + -ATPase activity in line with the correlation analyses. Consequently, while elevated levels of MDA in the rheumatoid arthritis group were suggestive of oxidative stress, a decreased Na + /K + -ATPase-activity led us to speculate that the cellular membrane had sustained injury. 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source EBSCOhost SPORTDiscus with Full Text
subjects Cell membranes
Free radicals
Malondialdehyde
Na+/K+-exchanging ATPase
Oxidative stress
Population studies
Rheumatoid arthritis
title Decreased Na + /K + pump activity in the erythrocyte membrane due to malondialdehyde in rheumatoid arthritis: an in vivo and in silico study
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