Cognitive profile of male mice exposed to a Ketogenic Diet

•KD increases β-hydroxybutyrate blood levels, without affecting bodyweight.•KD does not affect locomotor activity, memory, or hippocampal-dependent learning in mice.•Anxiety behavior in mice is increased 7 days after being fed with KD.•KD does not affect cognitive performance in mice. In recent year...

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Published in:Physiology & behavior 2022-10, Vol.254, p.113883-113883, Article 113883
Main Authors: Ródenas-González, Francisco, Blanco-Gandía, M.Carmen, Miñarro, José, Rodríguez-Arias, Marta
Format: Article
Language:English
Subjects:
Anxiety
autism
cognition
epilepsy
High-fat diet
Ketogenic diet
Ketosis
Learning
locomotion
Locomotor activity
males
Memory
Parkinson disease
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Summary:•KD increases β-hydroxybutyrate blood levels, without affecting bodyweight.•KD does not affect locomotor activity, memory, or hippocampal-dependent learning in mice.•Anxiety behavior in mice is increased 7 days after being fed with KD.•KD does not affect cognitive performance in mice. In recent years, nutritional interventions for different psychiatric diseases have gained increasing attention, such as the ketogenic diet (KD). This has led to positive effects in neurological disorders such as Parkinson's disease, addiction, autism or epilepsy. The neurobiological mechanisms through which these effects are induced and the effects in cognition still warrant investigation, and considering that other high-fat diets (HFD) can lead to cognitive disturbances that may affect the results achieved, the main aim of the present work was to evaluate the effects of a KD to determine whether it can induce such cognitive effects. A total of 30 OF1 male mice were employed to establish the behavioral profile of mice fed a KD by testing anxiety behavior (Elevated Plus Maze), locomotor activity (Open Field), learning (Hebb Williams Maze), and memory (Passive Avoidance Test). The results revealed that the KD did not affect locomotor activity, memory or hippocampal-dependent learning, as similar results were obtained with mice on a standard diet, albeit with increased anxiety behavior. We conclude that a KD is a promising nutritional approach to apply in research studies, given that it does not cause cognitive alterations.
ISSN:0031-9384
1873-507X
DOI:10.1016/j.physbeh.2022.113883