A sensitive method for the determination of 4-aminophenol using an electrochemical sensor based on 5-amino-1,3,4-thiadiazole-2-thiol

A new modified electrode (5AT2T-Au) was prepared by electrochemical deposition of 5-amino-1,3,4-thiadiazol-2-thiol (5AT2T) on the gold electrode (Au) surface to determine 4-aminophenol (4AP). First, the type and pH of the supporting electrolyte and voltammetric technique suitable for the determinati...

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Bibliographic Details
Published in:Journal of food composition and analysis 2022-12, Vol.114, p.104728, Article 104728
Main Authors: Tabanlıgil Calam, Tuğba, Taşkın Çakıcı, Gülşen
Format: Article
Language:English
Subjects:
4-aminophenol
aminophenols
detection limit
Drinking water
Electro-polymerization
electrochemistry
electrodes
electrolytes
food composition
gold
Milk
Modification
Response surface methodology
sensors (equipment)
syrups
Toxic
voltammetry
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Summary:A new modified electrode (5AT2T-Au) was prepared by electrochemical deposition of 5-amino-1,3,4-thiadiazol-2-thiol (5AT2T) on the gold electrode (Au) surface to determine 4-aminophenol (4AP). First, the type and pH of the supporting electrolyte and voltammetric technique suitable for the determination of 4AP were optimized. Response surface methodology (RSM) experimental design was used to achieve better analytical performance with the 5AT2T-Au sensor used. For this purpose, the effect of the combination of frequency (f), square wave amplitude (ΔEsw) and potential step (ΔEs) parameters of the square wave voltammetry technique (SWV) on the anodic peak current of the 4AP was investigated. Under the optimum parameter combination, for the determination of 4AP with the 5AT2T-Au electrode, the limit of detection (LOD) value was found as 2.82 nM, and the working range was obtained as two linear concentrations ranges 9.9 nM-2.24 µM and 2.24 µM-1.84 mM. The determination of 4AP in drinking water, children's syrup, and milk samples on the proposed sensor with satisfactory results were successfully applied. [Display omitted] •The usage of easy and fast prepared sensor for selective detection of 4AP•The sensor exhibited high sensitivity, wide linear range and low LOD value•Response surface method was used to optimize SWV parameters.•The practical, accurate and precise application of 4AP in real samples.
ISSN:0889-1575
1096-0481
DOI:10.1016/j.jfca.2022.104728