Assessment of mitochondrial dysfunction and implications in cardiovascular disorders

Mitochondria play a pivotal role in cellular function, not only acting as the powerhouse of the cell, but also regulating ATP synthesis, reactive oxygen species (ROS) production, intracellular Ca2+ cycling, and apoptosis. During the past decade, extensive progress has been made in the technology to...

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Bibliographic Details
Published in:Life sciences (1973) 2022-10, Vol.306, p.120834-120834, Article 120834
Main Authors: Li, Yuan, Ma, Ying, Dang, Qing-Ya, Fan, Xin-Rong, Han, Chu-Ting, Xu, Shang-Zhong, Li, Peng-Yun
Format: Article
Language:English
Subjects:
apoptosis
atherosclerosis
biogenesis
Ca2+ signaling
calcium
cardiomyopathy
chemical structure
drugs
energy
hypertension
mitochondria
Mitochondrial dynamics
Mitochondrial dysfunction
Mitochondrial energy metabolism
Mitochondrial permeability transition pore
myocardial ischemia
Oxidative stress
reactive oxygen species
therapeutics
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Summary:Mitochondria play a pivotal role in cellular function, not only acting as the powerhouse of the cell, but also regulating ATP synthesis, reactive oxygen species (ROS) production, intracellular Ca2+ cycling, and apoptosis. During the past decade, extensive progress has been made in the technology to assess mitochondrial functions and accumulating evidences have shown that mitochondrial dysfunction is a key pathophysiological mechanism for many diseases including cardiovascular disorders, such as ischemic heart disease, cardiomyopathy, hypertension, atherosclerosis, and hemorrhagic shock. The advances in methodology have been accelerating our understanding of mitochondrial molecular structure and function, biogenesis and ROS and energy production, which facilitates new drug target identification and therapeutic strategy development for mitochondrial dysfunction-related disorders. This review will focus on the assessment of methodologies currently used for mitochondrial research and discuss their advantages, limitations and the implications of mitochondrial dysfunction in cardiovascular disorders. [Display omitted]
ISSN:0024-3205
1879-0631
DOI:10.1016/j.lfs.2022.120834