Correlation between protein abundance and sequence conservation: what do recent experiments say?

Cells evolve in a space of parameter values set by physical and chemical forces. These constraints create associations among cellular properties. A particularly strong association is the negative correlation between the rate of evolution of proteins and their abundance in the cell. Highly expressed...

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Bibliographic Details
Published in:Current opinion in genetics & development 2022-12, Vol.77, p.101984-101984, Article 101984
Main Authors: Bédard, Camille, Cisneros, Angel F, Jordan, David, Landry, Christian R
Format: Article
Language:English
Subjects:
Evolution, Molecular
Proteins - genetics
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Summary:Cells evolve in a space of parameter values set by physical and chemical forces. These constraints create associations among cellular properties. A particularly strong association is the negative correlation between the rate of evolution of proteins and their abundance in the cell. Highly expressed proteins evolve slower than lowly expressed ones. Multiple hypotheses have been put forward to explain this relationship, including, for instance, the requirement for higher mRNA stability, misfolding avoidance, and misinteraction avoidance for highly expressed proteins. Here, we review some of these hypotheses, their predictions, and how they are supported to finally discuss recent experiments that have been performed to test these predictions.
ISSN:0959-437X
1879-0380
DOI:10.1016/j.gde.2022.101984