Ultrabright Renal-Clearable Cyanine-Protein Nanoprobes for High-Quality NIR-II Angiography and Lymphography

The renal-clearable aspect of imaging agent with minimum toxicity issues and side effects is essential for clinical translation, yet clinical near-infrared-I/II (NIR-I/II) fluorophores with timely renal-clearance pathways are very limited. Herein, we rationally develop the cyanine-protein composite...

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Bibliographic Details
Published in:Nano letters 2022-10, Vol.22 (19), p.7965-7975
Main Authors: Xu, Jiajun, Han, Tianyang, Wang, Yajun, Zhang, Feiran, Li, Mengfei, Bai, Lang, Wang, Xinyu, Sun, Bin, Wang, Xin, Du, Jianshi, Liu, Kun, Zhang, Junhu, Zhu, Shoujun
Format: Article
Language:English
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Summary:The renal-clearable aspect of imaging agent with minimum toxicity issues and side effects is essential for clinical translation, yet clinical near-infrared-I/II (NIR-I/II) fluorophores with timely renal-clearance pathways are very limited. Herein, we rationally develop the cyanine-protein composite strategy through covalent bonding of β-lactoglobulin (β-LG) and chloride-cyanine dye to produce a brilliant and stable NIR-I/II fluorophore (e.g., β-LG@IR-780). The β-LG acts as a protecting shell with small molecular weight (18.4 kDa) and ultrasmall size (
ISSN:1530-6984
1530-6992
DOI:10.1021/acs.nanolett.2c03311