Mechanistic elucidations of sesquiterpenes ameliorating viral infections: A review

• Published in: Journal of food biochemistry 2022-12, Vol.46 (12), p.e14452-n/a
• Main Authors: Katiyar, Deepti, Bansal, Priya, Kumar, Abhishek, Prakash, Surya, Rao, N. G. Raghavendra
• Format: Article
• Language: English
• Subjects: Antiviral Agents - pharmacology; biocatalysts; cyclization; Humans; isoprene; Plants; Prospective Studies; Sesquiterpenes - chemistry; Sesquiterpenes - pharmacology; synthesis; terpenoids; Virus Diseases - drug therapy
• ISSN: 0145-8884; 1745-4514
• DOI: 10.1111/jfbc.14452

Sesquiterpenes are important in human health because they can treat viral infection, cardiovascular disease, and cancer. Sesquiterpenes have also been shown to increase the sensitivity of tumor cells to conventional pharmacological therapies, in addition to their antiviral effects. The present review article was drafted with an intention to gather information regarding sesquiterpenes and its medicinal importance. The role of sesquiterpenes in the endogenous production of sesquiterpenes by plants and fungi, as well as the mechanisms by which they are effective against viral infection, are discussed in this review. Different online libraries such as PUBMED, Sciencedirect, MEDLINE were assessed to gather information, additionally, books, magzagines, journals, and scientific newspapaers were also studied to make this article more informative. This review examines novel synthesis mechanisms, their cyclization, purification techniques, and the diverse ecological roles sesquiterpenes play in the plant producer, which varies according to the plant and the chemical under consideration. In this article, we have discussed the consequences of sesquiterpenes and their properties for future crop productivity. We have addressed the many forms of sesquiterpenes that have been shown to have antiviral activity in various diseases. The consequences of sesquiterpenes and their properties are very useful for future crop productivity. We have addressed the many forms of sesquiterpenes that have been shown to have antiviral activity in the treatment of various diseases. Practical applications Novel synthesis mechanisms, their cyclization, purification techniques, and the diverse ecological roles of sesquiterpenes will be very helfpul in drug development process. Sesquiterpene lactones are shown in this review to have qualities that warrant further scientific investigation in order to stimulate preclinical and clinical trials leading to the creation of novel medications. For antiviral drug development, the sesquiterpenes are a good prospective lead molecule because they can suppress viral replication by disrupting vRNA production and viral protein production. A variety of naturally occuring sesquiterpenes could be promising lead moieties for the development of potent anti‐viral drugs.