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Can magnesium sulfate prophylaxis reduce colistin nephrotoxicity?
The study aimed to investigate the role of magnesium sulfate prophylaxis in nephrotoxicity caused by colistin. Thirty Wistar Albino rats were divided into four groups: control, colistin, magnesium (Mg), and Mg+colistin. The drugs were administered to the groups for seven days. Urea-creatinine values...
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| Published in: | Nefrología 2021-11, Vol.41 (6), p.661-669 |
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| creator | Yavuz, Yasemin Coşkun Cetin, Nihal Menevşe, Esma Cizmecioglu, Ahmet Celik, Esin Biyik, Zeynep Sevinc, Can Yavuz, Serkan Korez, Muslu Kazim Altintepe, Lutfullah |
| description | The study aimed to investigate the role of magnesium sulfate prophylaxis in nephrotoxicity caused by colistin. Thirty Wistar Albino rats were divided into four groups: control, colistin, magnesium (Mg), and Mg+colistin. The drugs were administered to the groups for seven days. Urea-creatinine values were measured at the beginning (T0) and end (T1) of the study. Malondialdehyde (MDA) levels were measured in plasma and kidney tissue, glutathione (GSH) levels were analyzed in the erythrocyte and kidney tissues. At the end of the study, the semiquantitative score (SQS) was calculated by the histopathological examination of the kidneys. Urea values significantly decreased in Mg and Mg+colistin groups compared to the baseline (p=0.013 and p=0.001). At the time of T1, these groups had significantly lower urea values than the colistin and control groups. Creatinine value was significantly increased in the colistin group compared to baseline (p=0.005), the creatinine value in the colistin group was significantly higher than the Mg+colistin group (p=0.011). Plasma MDA levels were significantly higher in the colistin group compared to the other groups at the time of T1 (p |
| doi_str_mv | 10.1016/j.nefroe.2022.01.005 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2718644081</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S2013251422000074</els_id><sourcerecordid>2718644081</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2495-8bb35372b46e0a9e341bba9f104235138b746d6a64cd8d057d28bd6ea20af7683</originalsourceid><addsrcrecordid>eNp9kDFPwzAUhC0EEqXwDxgysiQ8O46TLKCqooBUiQVmy7FfqKskDnaC2n9PqjAwMd0b7k7vPkJuKSQUqLjfJx3W3mHCgLEEaAKQnZEFA5rGLKP8_M99Sa5C2AOIjJX5gqzWqota9dlhsGMbhbGp1YBR712_OzbqYEPk0YwaI-0aGwbbRR32O-8Gd7DaDsfHa3JRqybgza8uycfm6X39Em_fnl_Xq22sGS-zuKiqNEtzVnGBoEpMOa0qVdYUOEszmhZVzoURSnBtCgNZblhRGYGKgapzUaRLcjf3Tr99jRgG2dqgsWlUh24MkuW0EJxDQScrn63auxA81rL3tlX-KCnIEzG5lzMxeSImgcqJ2BR7mGM4zfi26GXQFjuNxnrUgzTO_l_wAw4Edns</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2718644081</pqid></control><display><type>article</type><title>Can magnesium sulfate prophylaxis reduce colistin nephrotoxicity?</title><source>ScienceDirect Journals</source><creator>Yavuz, Yasemin Coşkun ; Cetin, Nihal ; Menevşe, Esma ; Cizmecioglu, Ahmet ; Celik, Esin ; Biyik, Zeynep ; Sevinc, Can ; Yavuz, Serkan ; Korez, Muslu Kazim ; Altintepe, Lutfullah</creator><creatorcontrib>Yavuz, Yasemin Coşkun ; Cetin, Nihal ; Menevşe, Esma ; Cizmecioglu, Ahmet ; Celik, Esin ; Biyik, Zeynep ; Sevinc, Can ; Yavuz, Serkan ; Korez, Muslu Kazim ; Altintepe, Lutfullah</creatorcontrib><description>The study aimed to investigate the role of magnesium sulfate prophylaxis in nephrotoxicity caused by colistin. Thirty Wistar Albino rats were divided into four groups: control, colistin, magnesium (Mg), and Mg+colistin. The drugs were administered to the groups for seven days. Urea-creatinine values were measured at the beginning (T0) and end (T1) of the study. Malondialdehyde (MDA) levels were measured in plasma and kidney tissue, glutathione (GSH) levels were analyzed in the erythrocyte and kidney tissues. At the end of the study, the semiquantitative score (SQS) was calculated by the histopathological examination of the kidneys. Urea values significantly decreased in Mg and Mg+colistin groups compared to the baseline (p=0.013 and p=0.001). At the time of T1, these groups had significantly lower urea values than the colistin and control groups. Creatinine value was significantly increased in the colistin group compared to baseline (p=0.005), the creatinine value in the colistin group was significantly higher than the Mg+colistin group (p=0.011). Plasma MDA levels were significantly higher in the colistin group compared to the other groups at the time of T1 (p<0.001). The Mg+colistin group had lower renal MDA levels than the colistin group. The colistin group had significantly higher renal tubular grade (p=0.035), renal affected area (p<0.001), and SQS (p=0.001) than the Mg+colistin group. The results of the study suggested that Mg sulfate may have a nephrotoxicity-reducing effect on colistin.
El objetivo del estudio fue investigar la función de la profilaxis con sulfato de magnesio en la nefrotoxicidad causada por la colistina. Se dividieron 30 ratas Wistar albinas en 4 grupos: control, colistina, magnesio (Mg) y Mg + colistina. Los fármacos se administraron a los grupos durante 7 días. Los valores de urea-creatinina se midieron al principio (T0) y al final (T1) del estudio. Se midieron los niveles de malondialdehído (MDA) en el plasma y el tejido renal, y se analizaron los niveles de glutatión (GSH) en los eritrocitos y el tejido renal. Al final del estudio, se calculó la puntuación semicuantitativa (semiquantitative score [SQS]) mediante el examen histopatológico de los riñones. Los valores de urea disminuyeron significativamente en los grupos de Mg y Mg + colistina en comparación con los valores iniciales (p = 0,013 y p = 0,001). En el momento del T1, estos grupos tenían valores de urea significativamente más bajos que los grupos de colistina y de control. El valor de creatinina se incrementó significativamente en el grupo de colistina en comparación con el valor inicial (p = 0,005); el valor de creatinina en el grupo de colistina fue significativamente mayor que en el grupo de Mg + colistina (p = 0,011). Los niveles de MDA en el plasma fueron significativamente más altos en el grupo de colistina en comparación con los otros grupos en el momento del T1 (p < 0,001). El grupo de Mg + colistina presentó niveles renales de MDA más bajos que el grupo de colistina. El grupo de colistina presentó un grado tubular renal (p = 0,035), un área renal afectada (p < 0,001) y una SQS (p = 0,001) significativamente mayores que el grupo de Mg + colistina. Los resultados del estudio indicaron que el sulfato de Mg puede tener un efecto reductor de la nefrotoxicidad de la colistina.</description><identifier>ISSN: 2013-2514</identifier><identifier>EISSN: 2013-2514</identifier><identifier>DOI: 10.1016/j.nefroe.2022.01.005</identifier><language>eng</language><publisher>Elsevier España, S.L.U</publisher><subject>Colistin ; Colistina ; Estrés oxidativo ; Magnesio ; Magnesium ; Modelo de rata ; Nefrotoxicidad ; Nephrotoxicity ; Oxidative stress ; Rat model</subject><ispartof>Nefrología, 2021-11, Vol.41 (6), p.661-669</ispartof><rights>2021 Sociedad Española de Nefrología</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2495-8bb35372b46e0a9e341bba9f104235138b746d6a64cd8d057d28bd6ea20af7683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S2013251422000074$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3549,27924,27925,45780</link.rule.ids></links><search><creatorcontrib>Yavuz, Yasemin Coşkun</creatorcontrib><creatorcontrib>Cetin, Nihal</creatorcontrib><creatorcontrib>Menevşe, Esma</creatorcontrib><creatorcontrib>Cizmecioglu, Ahmet</creatorcontrib><creatorcontrib>Celik, Esin</creatorcontrib><creatorcontrib>Biyik, Zeynep</creatorcontrib><creatorcontrib>Sevinc, Can</creatorcontrib><creatorcontrib>Yavuz, Serkan</creatorcontrib><creatorcontrib>Korez, Muslu Kazim</creatorcontrib><creatorcontrib>Altintepe, Lutfullah</creatorcontrib><title>Can magnesium sulfate prophylaxis reduce colistin nephrotoxicity?</title><title>Nefrología</title><description>The study aimed to investigate the role of magnesium sulfate prophylaxis in nephrotoxicity caused by colistin. Thirty Wistar Albino rats were divided into four groups: control, colistin, magnesium (Mg), and Mg+colistin. The drugs were administered to the groups for seven days. Urea-creatinine values were measured at the beginning (T0) and end (T1) of the study. Malondialdehyde (MDA) levels were measured in plasma and kidney tissue, glutathione (GSH) levels were analyzed in the erythrocyte and kidney tissues. At the end of the study, the semiquantitative score (SQS) was calculated by the histopathological examination of the kidneys. Urea values significantly decreased in Mg and Mg+colistin groups compared to the baseline (p=0.013 and p=0.001). At the time of T1, these groups had significantly lower urea values than the colistin and control groups. Creatinine value was significantly increased in the colistin group compared to baseline (p=0.005), the creatinine value in the colistin group was significantly higher than the Mg+colistin group (p=0.011). Plasma MDA levels were significantly higher in the colistin group compared to the other groups at the time of T1 (p<0.001). The Mg+colistin group had lower renal MDA levels than the colistin group. The colistin group had significantly higher renal tubular grade (p=0.035), renal affected area (p<0.001), and SQS (p=0.001) than the Mg+colistin group. The results of the study suggested that Mg sulfate may have a nephrotoxicity-reducing effect on colistin.
El objetivo del estudio fue investigar la función de la profilaxis con sulfato de magnesio en la nefrotoxicidad causada por la colistina. Se dividieron 30 ratas Wistar albinas en 4 grupos: control, colistina, magnesio (Mg) y Mg + colistina. Los fármacos se administraron a los grupos durante 7 días. Los valores de urea-creatinina se midieron al principio (T0) y al final (T1) del estudio. Se midieron los niveles de malondialdehído (MDA) en el plasma y el tejido renal, y se analizaron los niveles de glutatión (GSH) en los eritrocitos y el tejido renal. Al final del estudio, se calculó la puntuación semicuantitativa (semiquantitative score [SQS]) mediante el examen histopatológico de los riñones. Los valores de urea disminuyeron significativamente en los grupos de Mg y Mg + colistina en comparación con los valores iniciales (p = 0,013 y p = 0,001). En el momento del T1, estos grupos tenían valores de urea significativamente más bajos que los grupos de colistina y de control. El valor de creatinina se incrementó significativamente en el grupo de colistina en comparación con el valor inicial (p = 0,005); el valor de creatinina en el grupo de colistina fue significativamente mayor que en el grupo de Mg + colistina (p = 0,011). Los niveles de MDA en el plasma fueron significativamente más altos en el grupo de colistina en comparación con los otros grupos en el momento del T1 (p < 0,001). El grupo de Mg + colistina presentó niveles renales de MDA más bajos que el grupo de colistina. El grupo de colistina presentó un grado tubular renal (p = 0,035), un área renal afectada (p < 0,001) y una SQS (p = 0,001) significativamente mayores que el grupo de Mg + colistina. Los resultados del estudio indicaron que el sulfato de Mg puede tener un efecto reductor de la nefrotoxicidad de la colistina.</description><subject>Colistin</subject><subject>Colistina</subject><subject>Estrés oxidativo</subject><subject>Magnesio</subject><subject>Magnesium</subject><subject>Modelo de rata</subject><subject>Nefrotoxicidad</subject><subject>Nephrotoxicity</subject><subject>Oxidative stress</subject><subject>Rat model</subject><issn>2013-2514</issn><issn>2013-2514</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kDFPwzAUhC0EEqXwDxgysiQ8O46TLKCqooBUiQVmy7FfqKskDnaC2n9PqjAwMd0b7k7vPkJuKSQUqLjfJx3W3mHCgLEEaAKQnZEFA5rGLKP8_M99Sa5C2AOIjJX5gqzWqota9dlhsGMbhbGp1YBR712_OzbqYEPk0YwaI-0aGwbbRR32O-8Gd7DaDsfHa3JRqybgza8uycfm6X39Em_fnl_Xq22sGS-zuKiqNEtzVnGBoEpMOa0qVdYUOEszmhZVzoURSnBtCgNZblhRGYGKgapzUaRLcjf3Tr99jRgG2dqgsWlUh24MkuW0EJxDQScrn63auxA81rL3tlX-KCnIEzG5lzMxeSImgcqJ2BR7mGM4zfi26GXQFjuNxnrUgzTO_l_wAw4Edns</recordid><startdate>202111</startdate><enddate>202111</enddate><creator>Yavuz, Yasemin Coşkun</creator><creator>Cetin, Nihal</creator><creator>Menevşe, Esma</creator><creator>Cizmecioglu, Ahmet</creator><creator>Celik, Esin</creator><creator>Biyik, Zeynep</creator><creator>Sevinc, Can</creator><creator>Yavuz, Serkan</creator><creator>Korez, Muslu Kazim</creator><creator>Altintepe, Lutfullah</creator><general>Elsevier España, S.L.U</general><scope>6I.</scope><scope>AAFTH</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202111</creationdate><title>Can magnesium sulfate prophylaxis reduce colistin nephrotoxicity?</title><author>Yavuz, Yasemin Coşkun ; Cetin, Nihal ; Menevşe, Esma ; Cizmecioglu, Ahmet ; Celik, Esin ; Biyik, Zeynep ; Sevinc, Can ; Yavuz, Serkan ; Korez, Muslu Kazim ; Altintepe, Lutfullah</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2495-8bb35372b46e0a9e341bba9f104235138b746d6a64cd8d057d28bd6ea20af7683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Colistin</topic><topic>Colistina</topic><topic>Estrés oxidativo</topic><topic>Magnesio</topic><topic>Magnesium</topic><topic>Modelo de rata</topic><topic>Nefrotoxicidad</topic><topic>Nephrotoxicity</topic><topic>Oxidative stress</topic><topic>Rat model</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yavuz, Yasemin Coşkun</creatorcontrib><creatorcontrib>Cetin, Nihal</creatorcontrib><creatorcontrib>Menevşe, Esma</creatorcontrib><creatorcontrib>Cizmecioglu, Ahmet</creatorcontrib><creatorcontrib>Celik, Esin</creatorcontrib><creatorcontrib>Biyik, Zeynep</creatorcontrib><creatorcontrib>Sevinc, Can</creatorcontrib><creatorcontrib>Yavuz, Serkan</creatorcontrib><creatorcontrib>Korez, Muslu Kazim</creatorcontrib><creatorcontrib>Altintepe, Lutfullah</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nefrología</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yavuz, Yasemin Coşkun</au><au>Cetin, Nihal</au><au>Menevşe, Esma</au><au>Cizmecioglu, Ahmet</au><au>Celik, Esin</au><au>Biyik, Zeynep</au><au>Sevinc, Can</au><au>Yavuz, Serkan</au><au>Korez, Muslu Kazim</au><au>Altintepe, Lutfullah</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Can magnesium sulfate prophylaxis reduce colistin nephrotoxicity?</atitle><jtitle>Nefrología</jtitle><date>2021-11</date><risdate>2021</risdate><volume>41</volume><issue>6</issue><spage>661</spage><epage>669</epage><pages>661-669</pages><issn>2013-2514</issn><eissn>2013-2514</eissn><abstract>The study aimed to investigate the role of magnesium sulfate prophylaxis in nephrotoxicity caused by colistin. Thirty Wistar Albino rats were divided into four groups: control, colistin, magnesium (Mg), and Mg+colistin. The drugs were administered to the groups for seven days. Urea-creatinine values were measured at the beginning (T0) and end (T1) of the study. Malondialdehyde (MDA) levels were measured in plasma and kidney tissue, glutathione (GSH) levels were analyzed in the erythrocyte and kidney tissues. At the end of the study, the semiquantitative score (SQS) was calculated by the histopathological examination of the kidneys. Urea values significantly decreased in Mg and Mg+colistin groups compared to the baseline (p=0.013 and p=0.001). At the time of T1, these groups had significantly lower urea values than the colistin and control groups. Creatinine value was significantly increased in the colistin group compared to baseline (p=0.005), the creatinine value in the colistin group was significantly higher than the Mg+colistin group (p=0.011). Plasma MDA levels were significantly higher in the colistin group compared to the other groups at the time of T1 (p<0.001). The Mg+colistin group had lower renal MDA levels than the colistin group. The colistin group had significantly higher renal tubular grade (p=0.035), renal affected area (p<0.001), and SQS (p=0.001) than the Mg+colistin group. The results of the study suggested that Mg sulfate may have a nephrotoxicity-reducing effect on colistin.
El objetivo del estudio fue investigar la función de la profilaxis con sulfato de magnesio en la nefrotoxicidad causada por la colistina. Se dividieron 30 ratas Wistar albinas en 4 grupos: control, colistina, magnesio (Mg) y Mg + colistina. Los fármacos se administraron a los grupos durante 7 días. Los valores de urea-creatinina se midieron al principio (T0) y al final (T1) del estudio. Se midieron los niveles de malondialdehído (MDA) en el plasma y el tejido renal, y se analizaron los niveles de glutatión (GSH) en los eritrocitos y el tejido renal. Al final del estudio, se calculó la puntuación semicuantitativa (semiquantitative score [SQS]) mediante el examen histopatológico de los riñones. Los valores de urea disminuyeron significativamente en los grupos de Mg y Mg + colistina en comparación con los valores iniciales (p = 0,013 y p = 0,001). En el momento del T1, estos grupos tenían valores de urea significativamente más bajos que los grupos de colistina y de control. El valor de creatinina se incrementó significativamente en el grupo de colistina en comparación con el valor inicial (p = 0,005); el valor de creatinina en el grupo de colistina fue significativamente mayor que en el grupo de Mg + colistina (p = 0,011). Los niveles de MDA en el plasma fueron significativamente más altos en el grupo de colistina en comparación con los otros grupos en el momento del T1 (p < 0,001). El grupo de Mg + colistina presentó niveles renales de MDA más bajos que el grupo de colistina. El grupo de colistina presentó un grado tubular renal (p = 0,035), un área renal afectada (p < 0,001) y una SQS (p = 0,001) significativamente mayores que el grupo de Mg + colistina. Los resultados del estudio indicaron que el sulfato de Mg puede tener un efecto reductor de la nefrotoxicidad de la colistina.</abstract><pub>Elsevier España, S.L.U</pub><doi>10.1016/j.nefroe.2022.01.005</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Colistin Colistina Estrés oxidativo Magnesio Magnesium Modelo de rata Nefrotoxicidad Nephrotoxicity Oxidative stress Rat model |
| title | Can magnesium sulfate prophylaxis reduce colistin nephrotoxicity? |
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