Recent two-year advances in anti-dengue small-molecule inhibitors

Dengue is an acute tropical infectious disease transmitted by mosquitoes, which has posed a major challenge to global public health. Unfortunately, there is a lack of clinically proven dengue-specific drugs for its prevention and treatment. As the pathogenesis of dengue has not been fully elucidated...

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Bibliographic Details
Published in:European journal of medicinal chemistry 2022-12, Vol.243, p.114753-114753, Article 114753
Main Authors: Yang, Chao, Xie, Wansheng, Zhang, Heqian, Xie, Wenjian, Tian, Tiantian, Qin, Zhiwei
Format: Article
Language:English
Subjects:
Aedes aegypti
Dengue fever
Flaviviruses
Inhibitors
Tropical diseases
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Summary:Dengue is an acute tropical infectious disease transmitted by mosquitoes, which has posed a major challenge to global public health. Unfortunately, there is a lack of clinically proven dengue-specific drugs for its prevention and treatment. As the pathogenesis of dengue has not been fully elucidated, the development of specific drugs is seriously hindered. This article briefly describes the pathogenesis of dengue fever, the molecular characteristics, and epidemiology of dengue virus, and focuses on the potential small-molecule inhibitors of dengue virus, including on-target and multi-targeted inhibitors, which have been reported in the past two years. [Display omitted] •Potential targets for the development of anti-dengue drugs are summarized.•Elaboration on the infection and pathogenesis of dengue fever.•Natural products or Chinese herbal medicines are important candidate resources for developing anti-dengue drugs.
ISSN:0223-5234
1768-3254
DOI:10.1016/j.ejmech.2022.114753