Treatment with combined resveratrol and myoinositol ameliorates endocrine, metabolic alterations and perceived stress response in women with PCOS: a double-blind randomized clinical trial

• Published in: Endocrine 2023-01, Vol.79 (1), p.208-220
• Main Authors: Hassan, Sehresh, Shah, Mohsin, Malik, Muhammad Omar, Ehtesham, Ehtesham, Habib, Syed Hamid, Rauf, Bushra
• Format: Article
• Language: English
• Subjects: Adiponectin; Adult; Clinical trials; Diabetes; Double-blind studies; Endocrinology; Female; Follicle Stimulating Hormone; Humanities and Social Sciences; Humans; Inositol - pharmacology; Inositol - therapeutic use; Insulin; Internal Medicine; Luteinizing Hormone; Medicine; Medicine & Public Health; Menstruation; Metabolism; Metformin; Metformin - therapeutic use; multidisciplinary; Obesity - complications; Original Article; Pioglitazone; Pioglitazone - therapeutic use; Polycystic Ovary Syndrome; Resveratrol; Resveratrol - pharmacology; Resveratrol - therapeutic use; Risk groups; Science; Serum levels; Statistical analysis; Stress, Psychological; Testosterone; Young Adult
• ISSN: 1559-0100; 1355-008X; 1559-0100
• DOI: 10.1007/s12020-022-03198-2

Purpose The present study aimed to assess whether treatment with combined resveratrol and myoinositol is more effective in ameliorating the altered parameters associated with PCOS when compared to the combined metformin and pioglitazone therapy. Method One hundred and ten obese, oligo-anovulatory PCOS women, aged 20–35 years were randomly assigned into two treatment arms. Participants in arm-1 ( n  = 55), received combination of metformin and pioglitazone (500 mg and 15 mg, respectively), twice daily, while those in arm-2 ( n  = 55) received combination of resveratrol and myoinositol (1000 mg and 1000 mg, respectively) twice daily for 12 weeks. Evaluations performed at baseline were repeated after 3 months of therapy. The endocrine and metabolic derangements were assessed by measuring serum levels of testosterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH), adiponectin and insulin using ELISA. Cohen’s perceived stress scale (PSS) was employed as a subjective measure of stress. Results Pre-treatment PCOS women in both the arms (arm-1 and arm-2) had remarkably elevated serum testosterone and insulin concentrations, low serum adiponectin and high perceived stress response scores. The treatment reduced the altered endocrine indices in arm-2 (resveratrol and myoinositol) participants, manifested by statistically significant reduction in serum testosterone level ( p  = 0.001) and notably increased serum adiponectin level ( p  = 0.001). Interestingly, the hormonal profile, including serum LH and FSH levels also decreased ( p