Prevalence and clinical characteristics of patients with metabolic dysfunction‐associated fatty liver disease with hepatitis C virus infection—a population‐based study

Summary Background Metabolic‐associated fatty liver disease (MAFLD) was proposed in 2020 to identify fatty liver disease associated with metabolic risks. Metabolic abnormalities with hepatitis C virus (HCV) and MAFLD frequently co‐exist. However, data on the co‐existence are still lacking. Aim To ex...

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Published in:Alimentary pharmacology & therapeutics 2022-12, Vol.56 (11-12), p.1581-1590
Main Authors: Attia, Dina, Abdel Alem, Shereen, El‐Akel, Wafaa, Abdel‐Razek, Wael, Eslam, Mohamed, Fouad, Yasser, Waked, Imam
Format: Article
Language:English
Subjects:
Chronic infection
Diabetes
Diabetes mellitus
Diabetes Mellitus - epidemiology
Fatty liver
Fibrosis
Hepacivirus
Hepatitis C
Hepatitis C - complications
Humans
Hypertension
Hypertension - complications
Hypertension - epidemiology
Infections
Liver diseases
Metabolism
Non-alcoholic Fatty Liver Disease - complications
Non-alcoholic Fatty Liver Disease - diagnosis
Non-alcoholic Fatty Liver Disease - epidemiology
Obesity
Obesity - epidemiology
Patients
Population studies
Population-based studies
Prevalence
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Summary:Summary Background Metabolic‐associated fatty liver disease (MAFLD) was proposed in 2020 to identify fatty liver disease associated with metabolic risks. Metabolic abnormalities with hepatitis C virus (HCV) and MAFLD frequently co‐exist. However, data on the co‐existence are still lacking. Aim To explore the prevalence and characteristics of metabolic profiles among a large cohort of patients with HCV infection between 2007 and 2020 based on new diagnostic criteria Methods We recruited 288,222 patients with chronic HCV infection with demographic data, laboratory parameters, and ultrasound from a web‐based registry of the National Committee for Control of Viral Hepatitis in Egypt from 2007 to 2020. Results Among the participants, 41.9% (95% CI: 41.69–42.05) met diagnostic criteria for MAFLD, with a significant increase in the period 2014–2020 compared to 2007–2013 (43.3% vs. 19%, respectively). Participants with MAFLD had a high prevalence of obesity, diabetes mellitus and hypertension. The prevalences increased significantly over time (obesity: 66.7% vs. 76.9%, p 
ISSN:0269-2813
1365-2036
DOI:10.1111/apt.17233