Nitroisobenzofuranone, a small molecule inhibitor of multidrug-resistant Staphylococcus aureus , targets peptidoglycan biosynthesis

Antimicrobial resistance (AMR) is a global health concern. Targetting AMR, we present an in situ lactonization mechanism generating 4-nitroisobenzofuran-1(3 H )-one (IITK2020), an exclusive S. aureus inhibitor at 2–4 μg mL −1 MIC including multidrug-resistant S. aureus clinical strains, that prevent...

Full description

Saved in:
Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2022-10, Vol.58 (83), p.11669-11672
Main Authors: Rawat, Viral, Tiwari, Sona, Khanna, Shweta, Gupta, Umang, S. N. C., Sridhar, Yadav, Dharmendra K., Kaul, Grace, Akhir, Abdul, Saxena, Deepanshi, Matheshwaran, Saravanan, Chopra, Sidharth, Allimuthu, Dharmaraja
Format: Article
Language:English
Subjects:
Biosynthesis
Inhibitors
Public health
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Antimicrobial resistance (AMR) is a global health concern. Targetting AMR, we present an in situ lactonization mechanism generating 4-nitroisobenzofuran-1(3 H )-one (IITK2020), an exclusive S. aureus inhibitor at 2–4 μg mL −1 MIC including multidrug-resistant S. aureus clinical strains, that prevents peptidoglycan biosynthesis.
ISSN:1359-7345
1364-548X
DOI:10.1039/d2cc04102b