Organoids as a novel tool in modelling infectious diseases

Infectious diseases worldwide affect human health and have important societal impacts. A better understanding of infectious diseases is urgently needed. In vitro and in vivo infection models have brought notable contributions to the current knowledge of these diseases. Organoids are multicellular cu...

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Published in:Seminars in cell & developmental biology 2023-07, Vol.144, p.87-96
Main Authors: de Oliveira, Lucas Felipe, Filho, Daniel Mendes, Marques, Bruno Lemes, Maciel, Giovana Figueiredo, Parreira, Ricardo Cambraia, do Carmo Neto, José Rodrigues, Da Silva, Priscilla Elias Ferreira, Guerra, Rhanoica Oliveira, da Silva, Marcos Vinicius, Santiago, Helton da Costa, Birbrair, Alexander, Kihara, Alexandre H., Dias da Silva, Valdo José, Glaser, Talita, Resende, Rodrigo R., Ulrich, Henning
Format: Article
Language:English
Subjects:
Bioengineering
Communicable Diseases
Gastrointestinal Tract
Humans
Infection
Infectious disease
Organoid
Organoids
Stem cell
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Summary:Infectious diseases worldwide affect human health and have important societal impacts. A better understanding of infectious diseases is urgently needed. In vitro and in vivo infection models have brought notable contributions to the current knowledge of these diseases. Organoids are multicellular culture systems resembling tissue architecture and function, recapitulating many characteristics of human disease and elucidating mechanisms of host–infectious agent interactions in the respiratory and gastrointestinal systems, the central nervous system and the skin. Here, we discuss the applicability of the organoid technology for modeling pathogenesis, host response and features, which can be explored for the development of preventive and therapeutic treatments.
ISSN:1084-9521
1096-3634
DOI:10.1016/j.semcdb.2022.09.003