A novel U-shaped relationship between mitochondrial mass and risk of incomplete immune reconstitution in HIV-infected patients on antiviral therapy

Mitochondrial mass (MM) is considered an essential parameter of the immune system, but the association of MM with incomplete immune reconstitution (IIR) in people living with HIV (PLWH) remains unclear. Here, we tested 2148 blood samples from 1999 PLWH by flow cytometry in China between August 2021...

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Bibliographic Details
Published in:Clinical immunology (Orlando, Fla.) Fla.), 2022-12, Vol.245, p.109137-109137, Article 109137
Main Authors: Liu, Fang, Yang, Zongxing, Huang, Weiqiang, Zhang, Zhongdong, Shi, Jinchuan, Li, Guoping, Li, Jiamin, Zhang, Wenhui, Zheng, Guoxiang, Yan, Dingyan, Huang, Jinsong, Yu, Jianhua
Format: Article
Language:English
Subjects:
Antiretroviral Therapy, Highly Active
Antiviral Agents - therapeutic use
CD4 Lymphocyte Count
CD4+ T-cell counts
HIV
HIV Infections
Humans
Immune Reconstitution
Incomplete immune reconstitution
Mitochondrial mass
People living with HIV
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Summary:Mitochondrial mass (MM) is considered an essential parameter of the immune system, but the association of MM with incomplete immune reconstitution (IIR) in people living with HIV (PLWH) remains unclear. Here, we tested 2148 blood samples from 1999 PLWH by flow cytometry in China between August 2021 and February 2022. A novel U-shaped relationship, determined by multivariable smooth curve fitting and piecewise-linear mixed-effect model, was observed between the ratio of MM to SD (MM/SD) and IIR, with a threshold cutoff of 2.8. For MM/SD
ISSN:1521-6616
1521-7035
DOI:10.1016/j.clim.2022.109137