The diagnostic and prognostic utility of serum cystatin C and angiopoietin 2 in patients with liver cirrhosis complicated by acute kidney injury

Background Acute kidney injury (AKI) frequently affects patients with liver cirrhosis, diagnosed by changes in serum creatinine and urine output. This study aimed to evaluate the diagnostic and prognostic utility of serum cystatin C (Cys C) and angiopoietin 2 (Ang 2) in patients with liver cirrhosis...

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Published in:Therapeutic apheresis and dialysis 2023-06, Vol.27 (3), p.419-427
Main Authors: Abd El Wahab, Ahmed M., Awadeen, Abeer, Mansour, Mostafa M., Shemies, Rasha
Format: Article
Language:English
Subjects:
acute kidney injury
Acute Kidney Injury - diagnosis
Acute Kidney Injury - etiology
Angiopoietin-2
Biomarkers
chronic liver disease
Creatinine
Cystatin C
Humans
liver cirrhosis
Liver Cirrhosis - complications
Liver Cirrhosis - diagnosis
Predictive Value of Tests
Prognosis
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Summary:Background Acute kidney injury (AKI) frequently affects patients with liver cirrhosis, diagnosed by changes in serum creatinine and urine output. This study aimed to evaluate the diagnostic and prognostic utility of serum cystatin C (Cys C) and angiopoietin 2 (Ang 2) in patients with liver cirrhosis complicated by AKI. Methods A total of 81 cirrhotic patients with AKI were included. AKI was diagnosed according to Kidney Disease Improving Global Outcomes criteria. All patients were assessed clinically and biochemically. Baseline serum Cys C and Ang 2 were assessed, and patients were prospectively followed‐up to assess patients' and renal survival. Results Cys C significantly predicted AKI (p 
ISSN:1744-9979
1744-9987
DOI:10.1111/1744-9987.13936