The diagnostic and prognostic utility of serum cystatin C and angiopoietin 2 in patients with liver cirrhosis complicated by acute kidney injury

Background Acute kidney injury (AKI) frequently affects patients with liver cirrhosis, diagnosed by changes in serum creatinine and urine output. This study aimed to evaluate the diagnostic and prognostic utility of serum cystatin C (Cys C) and angiopoietin 2 (Ang 2) in patients with liver cirrhosis...

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Published in:Therapeutic apheresis and dialysis 2023-06, Vol.27 (3), p.419-427
Main Authors: Abd El Wahab, Ahmed M., Awadeen, Abeer, Mansour, Mostafa M., Shemies, Rasha
Format: Article
Language:English
Subjects:
acute kidney injury
Acute Kidney Injury - diagnosis
Acute Kidney Injury - etiology
Angiopoietin-2
Biomarkers
chronic liver disease
Creatinine
Cystatin C
Humans
liver cirrhosis
Liver Cirrhosis - complications
Liver Cirrhosis - diagnosis
Predictive Value of Tests
Prognosis
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container_end_page 427
container_issue 3
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container_title Therapeutic apheresis and dialysis
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creator Abd El Wahab, Ahmed M.
Awadeen, Abeer
Mansour, Mostafa M.
Shemies, Rasha
description Background Acute kidney injury (AKI) frequently affects patients with liver cirrhosis, diagnosed by changes in serum creatinine and urine output. This study aimed to evaluate the diagnostic and prognostic utility of serum cystatin C (Cys C) and angiopoietin 2 (Ang 2) in patients with liver cirrhosis complicated by AKI. Methods A total of 81 cirrhotic patients with AKI were included. AKI was diagnosed according to Kidney Disease Improving Global Outcomes criteria. All patients were assessed clinically and biochemically. Baseline serum Cys C and Ang 2 were assessed, and patients were prospectively followed‐up to assess patients' and renal survival. Results Cys C significantly predicted AKI (p 
doi_str_mv 10.1111/1744-9987.13936
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This study aimed to evaluate the diagnostic and prognostic utility of serum cystatin C (Cys C) and angiopoietin 2 (Ang 2) in patients with liver cirrhosis complicated by AKI. Methods A total of 81 cirrhotic patients with AKI were included. AKI was diagnosed according to Kidney Disease Improving Global Outcomes criteria. All patients were assessed clinically and biochemically. Baseline serum Cys C and Ang 2 were assessed, and patients were prospectively followed‐up to assess patients' and renal survival. Results Cys C significantly predicted AKI (p &lt; 0.001). Ang 2 (≤179.7 pg/ml) was an independent predictor of mortality in multivariate analysis. Marked ascites and partial pressure of carbon dioxide ≤ 29 were significant predictors of nonrenal recovery. Conclusion Cys C showed validity AKI diagnosis in cirrhotic patients while Ang 2 was an independent predictor of mortality.</description><identifier>ISSN: 1744-9979</identifier><identifier>EISSN: 1744-9987</identifier><identifier>DOI: 10.1111/1744-9987.13936</identifier><identifier>PMID: 36181409</identifier><language>eng</language><publisher>Kyoto, Japan: John Wiley &amp; Sons Australia, Ltd</publisher><subject>acute kidney injury ; Acute Kidney Injury - diagnosis ; Acute Kidney Injury - etiology ; Angiopoietin-2 ; Biomarkers ; chronic liver disease ; Creatinine ; Cystatin C ; Humans ; liver cirrhosis ; Liver Cirrhosis - complications ; Liver Cirrhosis - diagnosis ; Predictive Value of Tests ; Prognosis</subject><ispartof>Therapeutic apheresis and dialysis, 2023-06, Vol.27 (3), p.419-427</ispartof><rights>2022 International Society for Apheresis and Japanese Society for Apheresis.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3676-79c6a61b888a7e74daf9a2603048207b4827e4cc3c3cf3ac3063a99d3d5e51883</citedby><cites>FETCH-LOGICAL-c3676-79c6a61b888a7e74daf9a2603048207b4827e4cc3c3cf3ac3063a99d3d5e51883</cites><orcidid>0000-0002-0770-8023 ; 0000-0002-9873-0356</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36181409$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abd El Wahab, Ahmed M.</creatorcontrib><creatorcontrib>Awadeen, Abeer</creatorcontrib><creatorcontrib>Mansour, Mostafa M.</creatorcontrib><creatorcontrib>Shemies, Rasha</creatorcontrib><title>The diagnostic and prognostic utility of serum cystatin C and angiopoietin 2 in patients with liver cirrhosis complicated by acute kidney injury</title><title>Therapeutic apheresis and dialysis</title><addtitle>Ther Apher Dial</addtitle><description>Background Acute kidney injury (AKI) frequently affects patients with liver cirrhosis, diagnosed by changes in serum creatinine and urine output. This study aimed to evaluate the diagnostic and prognostic utility of serum cystatin C (Cys C) and angiopoietin 2 (Ang 2) in patients with liver cirrhosis complicated by AKI. Methods A total of 81 cirrhotic patients with AKI were included. AKI was diagnosed according to Kidney Disease Improving Global Outcomes criteria. All patients were assessed clinically and biochemically. Baseline serum Cys C and Ang 2 were assessed, and patients were prospectively followed‐up to assess patients' and renal survival. Results Cys C significantly predicted AKI (p &lt; 0.001). Ang 2 (≤179.7 pg/ml) was an independent predictor of mortality in multivariate analysis. Marked ascites and partial pressure of carbon dioxide ≤ 29 were significant predictors of nonrenal recovery. 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This study aimed to evaluate the diagnostic and prognostic utility of serum cystatin C (Cys C) and angiopoietin 2 (Ang 2) in patients with liver cirrhosis complicated by AKI. Methods A total of 81 cirrhotic patients with AKI were included. AKI was diagnosed according to Kidney Disease Improving Global Outcomes criteria. All patients were assessed clinically and biochemically. Baseline serum Cys C and Ang 2 were assessed, and patients were prospectively followed‐up to assess patients' and renal survival. Results Cys C significantly predicted AKI (p &lt; 0.001). Ang 2 (≤179.7 pg/ml) was an independent predictor of mortality in multivariate analysis. Marked ascites and partial pressure of carbon dioxide ≤ 29 were significant predictors of nonrenal recovery. 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source Wiley-Blackwell Read & Publish Collection
subjects acute kidney injury
Acute Kidney Injury - diagnosis
Acute Kidney Injury - etiology
Angiopoietin-2
Biomarkers
chronic liver disease
Creatinine
Cystatin C
Humans
liver cirrhosis
Liver Cirrhosis - complications
Liver Cirrhosis - diagnosis
Predictive Value of Tests
Prognosis
title The diagnostic and prognostic utility of serum cystatin C and angiopoietin 2 in patients with liver cirrhosis complicated by acute kidney injury
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