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Investigation of anterior segment structures of the eye in Behçet’s disease using in vivo confocal microscopy
Purpose We sought to investigate alterations in the corneal subbasal nerve plexus and endothelium in patients with Behçet’s disease (BD). Methods This cross-sectional study included 64 patients with BD and 30 age- and gender-matched healthy control subjects. Those with BD were classified as having o...
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Published in: | Graefe's archive for clinical and experimental ophthalmology 2022-12, Vol.260 (12), p.3897-3902 |
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creator | Dikmetas, Ozlem Aygün, Orhan Bolek, Ertugrul Çagri Kocabeyoglu, Sibel Karadag, Omer Karakaya, Jale Kadayıfçılar, Sibel Irkec, Murat |
description | Purpose
We sought to investigate alterations in the corneal subbasal nerve plexus and endothelium in patients with Behçet’s disease (BD).
Methods
This cross-sectional study included 64 patients with BD and 30 age- and gender-matched healthy control subjects. Those with BD were classified as having ocular or non-ocular disease. All subjects underwent a corneal endothelial and subbasal nerve density evaluation using in vivo confocal microscopy (IVCM). The differences among groups were analyzed using the Kruskal–Wallis test followed by Dunn’s multiple comparison procedure.
Results
The mean age of study participants was 35.7 ± 10.2 years (16–58) in the ocular BD group, 39.6 ± 14.9 years (11–66) in the non-ocular BD group, and 34.1 ± 11.2 years (21–55) in the control group. No statistical significance was found in terms of age (
p
= 0.259) or sex (
p
= 0.560) between groups. The mean endothelial cell density determined with IVCM was 2124.9
±
417.4 cells/mm
2
(1811–3275) in the ocular group and 2546
±
335 cells/mm
2
(1798–3280) in the control group (
p
= 0.000). In the ocular group, the mean density of the subbasal nerve plexus was significantly lower (
p
= 0.004), and nerve tortuosity was significantly higher (
p
= 0.002).
Conclusions
Ocular BD could be responsible for changes in the corneal layers, especially endothelial and corneal nerve structures. Nerve density and tortuosity differences could be inflammatory indicators for BD. |
doi_str_mv | 10.1007/s00417-022-05846-9 |
format | article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2720432492</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2736484898</sourcerecordid><originalsourceid>FETCH-LOGICAL-c282t-81acf52e93dd30146f48a291644ecbbe3904a9a6aa1df85f19e053e051b34e193</originalsourceid><addsrcrecordid>eNp9kU1OHDEQha0IpEyAC2RlKRs2nfivu-0lIAhISNmAxM7yeKoHoxl7cLlHml2ukRPkILkJJ8GdQYqUBYtSLeqrp1f1CPnM2VfOWP8NGVO8b5gQDWu16hrzgcy4km3TM_FwQGasF7zRUjx8JJ8Qn1jlZctnZHMTt4AlLF0JKdI0UBcL5JAyRViuIRaKJY--jBlwGpdHoLADGiI9h8c_v6G8_PyFdBEQHAIdMcTlNNyGbaI-xSF5t6Lr4HNCnza7Y3I4uBXCyVs_IvdXl3cX183tj-83F2e3jRdalEZz54dWgJGLhWRcdYPSThjeKQV-PgdpmHLGdc7xxaDbgRtgrazF51IBN_KInO51Nzk9j_VEuw7oYbVyEdKIVvSivkAoIyr65T_0KY05VneVkp3SShtdKbGnpksww2A3Oaxd3lnO7BSC3Ydgawj2bwh2ciH3S1jhuIT8T_qdrVe5wYz6</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2736484898</pqid></control><display><type>article</type><title>Investigation of anterior segment structures of the eye in Behçet’s disease using in vivo confocal microscopy</title><source>Springer Nature</source><creator>Dikmetas, Ozlem ; Aygün, Orhan ; Bolek, Ertugrul Çagri ; Kocabeyoglu, Sibel ; Karadag, Omer ; Karakaya, Jale ; Kadayıfçılar, Sibel ; Irkec, Murat</creator><creatorcontrib>Dikmetas, Ozlem ; Aygün, Orhan ; Bolek, Ertugrul Çagri ; Kocabeyoglu, Sibel ; Karadag, Omer ; Karakaya, Jale ; Kadayıfçılar, Sibel ; Irkec, Murat</creatorcontrib><description>Purpose
We sought to investigate alterations in the corneal subbasal nerve plexus and endothelium in patients with Behçet’s disease (BD).
Methods
This cross-sectional study included 64 patients with BD and 30 age- and gender-matched healthy control subjects. Those with BD were classified as having ocular or non-ocular disease. All subjects underwent a corneal endothelial and subbasal nerve density evaluation using in vivo confocal microscopy (IVCM). The differences among groups were analyzed using the Kruskal–Wallis test followed by Dunn’s multiple comparison procedure.
Results
The mean age of study participants was 35.7 ± 10.2 years (16–58) in the ocular BD group, 39.6 ± 14.9 years (11–66) in the non-ocular BD group, and 34.1 ± 11.2 years (21–55) in the control group. No statistical significance was found in terms of age (
p
= 0.259) or sex (
p
= 0.560) between groups. The mean endothelial cell density determined with IVCM was 2124.9
±
417.4 cells/mm
2
(1811–3275) in the ocular group and 2546
±
335 cells/mm
2
(1798–3280) in the control group (
p
= 0.000). In the ocular group, the mean density of the subbasal nerve plexus was significantly lower (
p
= 0.004), and nerve tortuosity was significantly higher (
p
= 0.002).
Conclusions
Ocular BD could be responsible for changes in the corneal layers, especially endothelial and corneal nerve structures. Nerve density and tortuosity differences could be inflammatory indicators for BD.</description><identifier>ISSN: 0721-832X</identifier><identifier>EISSN: 1435-702X</identifier><identifier>DOI: 10.1007/s00417-022-05846-9</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Behcet's syndrome ; Cell density ; Confocal microscopy ; Cornea ; Endothelial cells ; Endothelium ; Inflammation ; Medicine ; Medicine & Public Health ; Microscopy ; Ophthalmology ; Vein & artery diseases</subject><ispartof>Graefe's archive for clinical and experimental ophthalmology, 2022-12, Vol.260 (12), p.3897-3902</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c282t-81acf52e93dd30146f48a291644ecbbe3904a9a6aa1df85f19e053e051b34e193</citedby><cites>FETCH-LOGICAL-c282t-81acf52e93dd30146f48a291644ecbbe3904a9a6aa1df85f19e053e051b34e193</cites><orcidid>0000-0001-5670-2384</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Dikmetas, Ozlem</creatorcontrib><creatorcontrib>Aygün, Orhan</creatorcontrib><creatorcontrib>Bolek, Ertugrul Çagri</creatorcontrib><creatorcontrib>Kocabeyoglu, Sibel</creatorcontrib><creatorcontrib>Karadag, Omer</creatorcontrib><creatorcontrib>Karakaya, Jale</creatorcontrib><creatorcontrib>Kadayıfçılar, Sibel</creatorcontrib><creatorcontrib>Irkec, Murat</creatorcontrib><title>Investigation of anterior segment structures of the eye in Behçet’s disease using in vivo confocal microscopy</title><title>Graefe's archive for clinical and experimental ophthalmology</title><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><description>Purpose
We sought to investigate alterations in the corneal subbasal nerve plexus and endothelium in patients with Behçet’s disease (BD).
Methods
This cross-sectional study included 64 patients with BD and 30 age- and gender-matched healthy control subjects. Those with BD were classified as having ocular or non-ocular disease. All subjects underwent a corneal endothelial and subbasal nerve density evaluation using in vivo confocal microscopy (IVCM). The differences among groups were analyzed using the Kruskal–Wallis test followed by Dunn’s multiple comparison procedure.
Results
The mean age of study participants was 35.7 ± 10.2 years (16–58) in the ocular BD group, 39.6 ± 14.9 years (11–66) in the non-ocular BD group, and 34.1 ± 11.2 years (21–55) in the control group. No statistical significance was found in terms of age (
p
= 0.259) or sex (
p
= 0.560) between groups. The mean endothelial cell density determined with IVCM was 2124.9
±
417.4 cells/mm
2
(1811–3275) in the ocular group and 2546
±
335 cells/mm
2
(1798–3280) in the control group (
p
= 0.000). In the ocular group, the mean density of the subbasal nerve plexus was significantly lower (
p
= 0.004), and nerve tortuosity was significantly higher (
p
= 0.002).
Conclusions
Ocular BD could be responsible for changes in the corneal layers, especially endothelial and corneal nerve structures. Nerve density and tortuosity differences could be inflammatory indicators for BD.</description><subject>Behcet's syndrome</subject><subject>Cell density</subject><subject>Confocal microscopy</subject><subject>Cornea</subject><subject>Endothelial cells</subject><subject>Endothelium</subject><subject>Inflammation</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Microscopy</subject><subject>Ophthalmology</subject><subject>Vein & artery diseases</subject><issn>0721-832X</issn><issn>1435-702X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kU1OHDEQha0IpEyAC2RlKRs2nfivu-0lIAhISNmAxM7yeKoHoxl7cLlHml2ukRPkILkJJ8GdQYqUBYtSLeqrp1f1CPnM2VfOWP8NGVO8b5gQDWu16hrzgcy4km3TM_FwQGasF7zRUjx8JJ8Qn1jlZctnZHMTt4AlLF0JKdI0UBcL5JAyRViuIRaKJY--jBlwGpdHoLADGiI9h8c_v6G8_PyFdBEQHAIdMcTlNNyGbaI-xSF5t6Lr4HNCnza7Y3I4uBXCyVs_IvdXl3cX183tj-83F2e3jRdalEZz54dWgJGLhWRcdYPSThjeKQV-PgdpmHLGdc7xxaDbgRtgrazF51IBN_KInO51Nzk9j_VEuw7oYbVyEdKIVvSivkAoIyr65T_0KY05VneVkp3SShtdKbGnpksww2A3Oaxd3lnO7BSC3Ydgawj2bwh2ciH3S1jhuIT8T_qdrVe5wYz6</recordid><startdate>20221201</startdate><enddate>20221201</enddate><creator>Dikmetas, Ozlem</creator><creator>Aygün, Orhan</creator><creator>Bolek, Ertugrul Çagri</creator><creator>Kocabeyoglu, Sibel</creator><creator>Karadag, Omer</creator><creator>Karakaya, Jale</creator><creator>Kadayıfçılar, Sibel</creator><creator>Irkec, Murat</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5670-2384</orcidid></search><sort><creationdate>20221201</creationdate><title>Investigation of anterior segment structures of the eye in Behçet’s disease using in vivo confocal microscopy</title><author>Dikmetas, Ozlem ; Aygün, Orhan ; Bolek, Ertugrul Çagri ; Kocabeyoglu, Sibel ; Karadag, Omer ; Karakaya, Jale ; Kadayıfçılar, Sibel ; Irkec, Murat</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c282t-81acf52e93dd30146f48a291644ecbbe3904a9a6aa1df85f19e053e051b34e193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Behcet's syndrome</topic><topic>Cell density</topic><topic>Confocal microscopy</topic><topic>Cornea</topic><topic>Endothelial cells</topic><topic>Endothelium</topic><topic>Inflammation</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Microscopy</topic><topic>Ophthalmology</topic><topic>Vein & artery diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dikmetas, Ozlem</creatorcontrib><creatorcontrib>Aygün, Orhan</creatorcontrib><creatorcontrib>Bolek, Ertugrul Çagri</creatorcontrib><creatorcontrib>Kocabeyoglu, Sibel</creatorcontrib><creatorcontrib>Karadag, Omer</creatorcontrib><creatorcontrib>Karakaya, Jale</creatorcontrib><creatorcontrib>Kadayıfçılar, Sibel</creatorcontrib><creatorcontrib>Irkec, Murat</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection (ProQuest Medical & Health Databases)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dikmetas, Ozlem</au><au>Aygün, Orhan</au><au>Bolek, Ertugrul Çagri</au><au>Kocabeyoglu, Sibel</au><au>Karadag, Omer</au><au>Karakaya, Jale</au><au>Kadayıfçılar, Sibel</au><au>Irkec, Murat</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Investigation of anterior segment structures of the eye in Behçet’s disease using in vivo confocal microscopy</atitle><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle><stitle>Graefes Arch Clin Exp Ophthalmol</stitle><date>2022-12-01</date><risdate>2022</risdate><volume>260</volume><issue>12</issue><spage>3897</spage><epage>3902</epage><pages>3897-3902</pages><issn>0721-832X</issn><eissn>1435-702X</eissn><abstract>Purpose
We sought to investigate alterations in the corneal subbasal nerve plexus and endothelium in patients with Behçet’s disease (BD).
Methods
This cross-sectional study included 64 patients with BD and 30 age- and gender-matched healthy control subjects. Those with BD were classified as having ocular or non-ocular disease. All subjects underwent a corneal endothelial and subbasal nerve density evaluation using in vivo confocal microscopy (IVCM). The differences among groups were analyzed using the Kruskal–Wallis test followed by Dunn’s multiple comparison procedure.
Results
The mean age of study participants was 35.7 ± 10.2 years (16–58) in the ocular BD group, 39.6 ± 14.9 years (11–66) in the non-ocular BD group, and 34.1 ± 11.2 years (21–55) in the control group. No statistical significance was found in terms of age (
p
= 0.259) or sex (
p
= 0.560) between groups. The mean endothelial cell density determined with IVCM was 2124.9
±
417.4 cells/mm
2
(1811–3275) in the ocular group and 2546
±
335 cells/mm
2
(1798–3280) in the control group (
p
= 0.000). In the ocular group, the mean density of the subbasal nerve plexus was significantly lower (
p
= 0.004), and nerve tortuosity was significantly higher (
p
= 0.002).
Conclusions
Ocular BD could be responsible for changes in the corneal layers, especially endothelial and corneal nerve structures. Nerve density and tortuosity differences could be inflammatory indicators for BD.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1007/s00417-022-05846-9</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-5670-2384</orcidid></addata></record> |
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issn | 0721-832X 1435-702X |
language | eng |
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source | Springer Nature |
subjects | Behcet's syndrome Cell density Confocal microscopy Cornea Endothelial cells Endothelium Inflammation Medicine Medicine & Public Health Microscopy Ophthalmology Vein & artery diseases |
title | Investigation of anterior segment structures of the eye in Behçet’s disease using in vivo confocal microscopy |
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