Recent advances in C–H functionalization of 2H-indazoles

2H-Indazoles are one class of the most important nitrogen-containing heterocyclic compounds. The 2H-indazole motif is widely present in bioactive natural products and drug molecules that exhibit distinctive bioactivities. Therefore, much attention has been paid to access diverse 2H-indazole derivati...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2022-10, Vol.20 (39), p.7746-7764
Main Authors: Yang, Zixian, Jin-Tao, Yu, Pan, Changduo
Format: Article
Language:English
Subjects:
Benzene
Biological activity
Heterocyclic compounds
Natural products
Transition metals
Online Access:Get full text
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Summary:2H-Indazoles are one class of the most important nitrogen-containing heterocyclic compounds. The 2H-indazole motif is widely present in bioactive natural products and drug molecules that exhibit distinctive bioactivities. Therefore, much attention has been paid to access diverse 2H-indazole derivatives. Among them, the late-stage functionalization of 2H-indazoles via C–H activation is recognized as an efficient approach for increasing the complexity and diversity of 2H-indazole derivatives. In this review, we summarized recent achievements in the late-stage functionalization of 2H-indazoles, including the C3-functionalization of 2H-indazoles through transition metal-catalyzed C–H activation or a radical pathway, transition metal-catalyzed ortho C2′–H functionalization of 2H-indazoles and remote C–H functionalization at the benzene ring in 2H-indazoles.
ISSN:1477-0520
1477-0539
DOI:10.1039/d2ob01463g