Delayed type hypersensitivity reactions to various allergens may differently model inflammatory skin diseases

Background Treatment of inflammatory skin diseases, including atopic dermatitis (AD) and psoriasis, is undergoing transformative changes, highlighting the need to develop experimental models of skin inflammation in humans to predict treatment responses. Methods We topically or intradermally administ...

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Bibliographic Details
Published in:Allergy (Copenhagen) 2023-01, Vol.78 (1), p.178-191
Main Authors: Pavel, Ana B., Del Duca, Ester, Cheng, Julia, Wu, Jianni, Ungar, Benjamin, Estrada, Yeriel D., Jack, Carolyn, Maari, Catherine, Proulx, Étienne Saint‐Cyr, Ramirez‐Valle, Francisco, Krueger, James G., Bissonnette, Robert, Guttman‐Yassky, Emma
Format: Article
Language:English
Subjects:
Allergens
allergic contact dermatitis
Atopic dermatitis
biomarker
CCL17 protein
CCL18 protein
contact dermatitis
CXCL10 protein
Cytokines - metabolism
Dendritic cells
Dermatitis, Atopic
Eczema
Foxp3 protein
Helper cells
Humans
Hypersensitivity (delayed)
Immunohistochemistry
inflammation
Inflammation - pathology
inflammatory skin disease
Innate immunity
Interleukin-17
Lipid metabolism
Lymphocytes T
Nickel
Nickel - adverse effects
Psoriasis
Skin - pathology
Skin diseases
Stat1 protein
Th17 Cells
Th2 Cells
Tuberculin
γ-Interferon
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Summary:Background Treatment of inflammatory skin diseases, including atopic dermatitis (AD) and psoriasis, is undergoing transformative changes, highlighting the need to develop experimental models of skin inflammation in humans to predict treatment responses. Methods We topically or intradermally administered four common sensitizers (dust mite (DM), diphencyprone (DPCP), nickel (Ni), and purified protein derivative (PPD)) to the backs of 40 healthy patients and the skin hypersensitivity response was biopsied and evaluated using immunohistochemistry, RNA‐seq, and RT‐PCR. Results All agents induced strong increases in cellular infiltrates (T‐cells and dendritic cells) as compared to untreated skin (p 
ISSN:0105-4538
1398-9995
DOI:10.1111/all.15538