Analysis of PPP1R11 expression in granulosa cells during developmental follicles of yak and its effects on cell function

The aims of this study were to analyse the protein phosphatase 1 regulatory subunit 11 (PPP1R11) expression and cellular localization in yak follicles and investigate its effects on cell proliferation, apoptosis and oestrogen secretion in granulosa cells (GCs). Ten healthy and non‐pregnant female ya...

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Bibliographic Details
Published in:Reproduction in domestic animals 2023-01, Vol.58 (1), p.129-140
Main Authors: Min, Xingyu, Zhu, Yanjin, Hu, Yulei, Yang, Manzhen, Yu, Hailing, Xiong, Yan, Fu, Wei, Li, Jian, Matsuda, Fuko, Xiong, Xianrong
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Apoptosis - physiology
BAX protein
Cattle
Cell culture
Cell growth
Cell proliferation
Enzyme-linked immunosorbent assay
Estrogens
Estrogens - metabolism
Female
follicle development
Follicles
Gene expression
Genes
Granulosa cells
Granulosa Cells - metabolism
Immunofluorescence
Immunohistochemistry
Interference
Localization
mRNA
Ovary - metabolism
p53 Protein
Phosphoprotein phosphatase
PPP1R11
Protein phosphatase
Protein Phosphatase 1 - metabolism
Proteins
Regulatory mechanisms (biology)
RNA, Messenger - metabolism
Staining
Transfection
yak
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Summary:The aims of this study were to analyse the protein phosphatase 1 regulatory subunit 11 (PPP1R11) expression and cellular localization in yak follicles and investigate its effects on cell proliferation, apoptosis and oestrogen secretion in granulosa cells (GCs). Ten healthy and non‐pregnant female yaks (4‐year‐old) were used as experimental animals. The mRNA relative expression level of PPP1R11 in GCs from small (
ISSN:0936-6768
1439-0531
DOI:10.1111/rda.14272