Microwave in situ inactivation in the treatment of bone giant cell tumor: a mid-term descriptive study

Aim To evaluate the mid-term clinical efficacy of microwave in situ inactivation combined with bone grafting or polymethyl methacrylate (PMMA) filling in the treatment of giant cell tumor of bone (GCTB). Methods This is a retrospective, descriptive, and analytical study. A total of 30 GCTB patients...

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Published in:Journal of cancer research and clinical oncology 2023-07, Vol.149 (8), p.4653-4661
Main Authors: Jiang, Xiang, Chen, Jianan, Zhou, Wei, Zhang, Chen, Wang, Guodong, Dong, Dan, Xia, Pingguang, Liu, Ximing, Xu, Feng
Format: Article
Language:English
Subjects:
Bone grafts
Cancer Research
Femur
Hematology
Internal Medicine
Long bone
Medicine
Medicine & Public Health
Metastases
Oncology
Patients
Polymethyl methacrylate
Polymethylmethacrylate
Skin & tissue grafts
Tibia
Tumors
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Summary:Aim To evaluate the mid-term clinical efficacy of microwave in situ inactivation combined with bone grafting or polymethyl methacrylate (PMMA) filling in the treatment of giant cell tumor of bone (GCTB). Methods This is a retrospective, descriptive, and analytical study. A total of 30 GCTB patients received microwave in situ inactivation from January 2012 to January 2020, whose clinical recurrence rate was evaluated at the last follow-up after microwave in situ inactivation surgery. The Musculoskeletal Tumor Society (MSTS) function score was used to evaluate the postoperative clinical panoramic results. Results All patients were followed up for 21 to 110 months, with an average of 63.79 months. Distal femur (40%) and proximal tibia (28%) had a higher rate of GCTB incidence. Seventeen percent of tumor patients suffered from associated pathologic fracture. The rate of Campanacci classification stage III was 60%. The average MSTS score was evaluated as 27.53 points overall at the last follow-up. In terms of complications, three, two, two and one cases developed fat liquefaction, controllable tissue rejection reaction, incision infection and degenerative changes around lesion joint, respectively, without in situ recurrences and reoperation as well as distant lung metastasis. Conclusions The method of microwave in situ inactivation combined with bone grafting or PMMA filling is prudently recommended as one of the options for the limb salvage treatment of giant cell tumor of long and periarticular bone. Level of evidence IV: case series.
ISSN:0171-5216
1432-1335
DOI:10.1007/s00432-022-04348-9