Novel rechargeable nano-calcium phosphate and nano-calcium fluoride resin cements

In most clinical circumstances, secondary caries at the margin of fixed dental restorations leads to restoration failure and replacement. Accordingly, the objectives of this study were to: (1) develop a novel rechargeable nano-calcium phosphate (NACP) and nano-calcium fluoride (nCaF2) resin-based ce...

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Bibliographic Details
Published in:Journal of dentistry 2022-11, Vol.126, p.104312-104312, Article 104312
Main Authors: AlSahafi, Rashed, Mitwalli, Heba, Alhussein, Abdullah, Balhaddad, Abdulrahman A., Alquria, Theeb A, Melo, Mary Anne S., Lynch, Christopher D., Oates, Thomas W., Zhang, Ke, Xu, Hockin.H.K., Weir, Michael D.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents
Bio-interactive
Biofilms
Bisphenol A
Bonding strength
Calcium Fluoride
Calcium fluoride nanoparticles
Calcium phosphate nanoparticles
Calcium phosphates
Calcium Phosphates - chemistry
Demineralization
Demineralizing
Dental caries
Dental Caries - prevention & control
Dental cement
Dental Cements - chemistry
Dental Materials
Dentin
Dentistry
Enamel
Film thickness
Flexural strength
Fluorides
Glycerol
Humans
Ions
Mechanical properties
Methacrylates - chemistry
Minerals
Nanoparticles
Particle size
Remineralization
Remineralizing
Resin Cements
Resins
Survivability
Teeth
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Summary:In most clinical circumstances, secondary caries at the margin of fixed dental restorations leads to restoration failure and replacement. Accordingly, the objectives of this study were to: (1) develop a novel rechargeable nano-calcium phosphate (NACP) and nano-calcium fluoride (nCaF2) resin-based cement; and (2) investigate their mechanical properties and calcium (Ca), phosphate (P), and fluoride (F) ion release, recharge, and re-release for the first time. The cement matrix consisted of pyromellitic glycerol dimethacrylate (PMGDM), ethoxylated bisphenol-A-dimethacrylate (EBPADMA) was denoted PEHB. Four cements were fabricated: (1) PEHB+0%NACP+0%nCaF2 (experimental control); (2) PEHB+25%NACP+0%nCaF2, (3) PEHB+0%NACP+25%nCaF2; (4) PEHB+12.5%NACP+12.5% nCaF2. RelyX luting cement was used as a commercial control. Mechanical properties and long-term Ca, P, and F ion release, recharge, and re-release were evaluated. Adding 25% NACP, 25% nCaF2 and adding both 12.5% NACP and 12.5% nCaF2 to the cement matrix presented a significantly higher shear bond strength, flexural strength compared to the commercial control (p < 0.05) with a comparable outcome with no significant different (p > 0.05) compared to experimental control. The film thickness results of all cement groups met the ISO requirement (
ISSN:0300-5712
1879-176X
DOI:10.1016/j.jdent.2022.104312