The influence of hypertension management on frailty prevention among older persons aged 65 and over: a systematic review

Background Frailty and hypertension are interrelated, but it remains unclear whether this relationship is modified by antihypertensive drugs. Methods and results A systematic review of PubMed and Web of Science databases was performed to review the influence of hypertension management on preventing...

Full description

Saved in:
Bibliographic Details
Published in:Aging clinical and experimental research 2022-11, Vol.34 (11), p.2645-2657
Main Authors: Qipo, Orgesa, Debain, Aziz, Bautmans, Ivan
Format: Article
Language:English
Subjects:
Frailty
Geriatrics/Gerontology
Hypertension
Medicine
Medicine & Public Health
Older people
Review Article
Systematic review
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Frailty and hypertension are interrelated, but it remains unclear whether this relationship is modified by antihypertensive drugs. Methods and results A systematic review of PubMed and Web of Science databases was performed to review the influence of hypertension management on preventing the occurrence or progression of frailty in older people aged 65 and over. Studies providing information on this association regardless of the study setting, or definition of hypertension and frailty were included. Among the initial 2298 articles identified, 7 were included in the review. Three observational studies assessed the association between frailty and hypertension. Two of them reported no relationship between Aldosterone Antagonists use and frailty prevention. No relationship between BP and incidence frailty after adjustment for hypertension treatment was observed in two other articles. An indirect relationship was reported in the RCTs included. Higher AT11RaAb levels (control group), can lead to a generalized weakness/frailty risk shown by a decrease in grip strength ( r  = –0.57, p  
ISSN:1720-8319
1594-0667
1720-8319
DOI:10.1007/s40520-022-02247-0