Electrochemically Promoted [3 + 2] Annulation of Imidazo[1,2‑a]pyridine with Alkynes

The efficient electrochemically promoted [3 + 2] annulation of imidazo­[1,2-a]­pyridines with alkynes using traceless electrons as green reagents has been developed, leading to the synthesis of a large class of polycyclic heteroaromatics in good yields with a broad substrate scope under mild and gre...

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Bibliographic Details
Published in:Organic letters 2022-10, Vol.24 (40), p.7410-7415
Main Authors: Ping, Meng-Qi, Guo, Ming-Zhong, Li, Rui-Tao, Wang, Zi-Chen, Ma, Cheng, Wen, Li-Rong, Ni, Shao-Fei, Guo, Weisi, Li, Ming, Zhang, Lin-Bao
Format: Article
Language:English
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Summary:The efficient electrochemically promoted [3 + 2] annulation of imidazo­[1,2-a]­pyridines with alkynes using traceless electrons as green reagents has been developed, leading to the synthesis of a large class of polycyclic heteroaromatics in good yields with a broad substrate scope under mild and green conditions. The scaled-up experiment, follow-up procedures, and potential biological applications show the practicability and feasibility of the electrochemical method.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.2c02980