The Promoting Effect of a Local Pulsatile Parathyroid Hormone Delivery on Healing of the Mandibular Fracture in Rats

Parathyroid hormone (PTH) can promote bone formation and mineralization in mandibular fractures, and is systemically administered through daily injections. In this study, the local delivery of PTH using carboxymethyl chitosan/polyvinyl alcohol and alginate was investigated. Bovine serum albumin was...

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Published in:Tissue engineering. Part A 2023-02, Vol.29 (3-4), p.69-79
Main Authors: Jia, Yuanyuan, Duan, Mianmian, Yang, Yan, Wang, Dongxiang, Dong, Qiang, Liao, Jian, Mao, Ling, Liu, Poyu, Feng, Ling, Chen, Jin, Tang, Zhenglong
Format: Article
Language:English
Subjects:
Alginic acid
Animals
Biocompatibility
Biodegradability
Bone biomaterials
Bone growth
Bone healing
Bone Regeneration
Bovine serum albumin
Chitosan
Drug delivery
Fracture Healing
Fractures
Mandible
Mandibular Fractures - drug therapy
Mineralization
Original Articles
Osteogenesis
Parathyroid hormone
Parathyroid Hormone - pharmacology
Polyvinyl alcohol
Radiography
Rats
Rats, Sprague-Dawley
Regeneration
Tissue engineering
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Summary:Parathyroid hormone (PTH) can promote bone formation and mineralization in mandibular fractures, and is systemically administered through daily injections. In this study, the local delivery of PTH using carboxymethyl chitosan/polyvinyl alcohol and alginate was investigated. Bovine serum albumin was used as a drug substitute, and the delivery system was verified to release drugs in a pulsed rhythm. After the delivery system was subcutaneously implanted in Sprague–Dawley (SD) rats, no rejection reaction was detected, indicating that it has good biocompatibility and biodegradability in vivo . Then, an SD rat model of mandibular fracture was established, and 24 rats were randomly divided into two groups. The control group was reduced and fixed with screws and a microplate, and the experimental group received pulsatile PTH release system (14 μg PTH) + screws and microplate fixation. The animals were euthanized on postoperative weeks 1–4. Observation of gross specimens, digital radiography, and hematoxylin and eosin showed that the local PTH pulsatile release system promoted osteogenesis and accelerated fracture healing. In summary, PTH can be loaded by biomaterials to locally target the fracture and stimulate bone formation. Moreover, the pulsatile PTH release system provides a potential therapeutic protocol for mandibular fracture.
ISSN:1937-3341
1937-335X
DOI:10.1089/ten.tea.2022.0136