Coagulation assays and direct oral anticoagulant levels among patients having an elective surgery or procedure

Background The Perioperative Anticoagulation Use for Surgery Evaluation study prospectively evaluated a prespecified periprocedural interruption strategy of direct oral anticoagulants (DOACs) among patients with atrial fibrillation. Coagulation testing is widely available and frequently requested pr...

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Bibliographic Details
Published in:Journal of thrombosis and haemostasis 2022-12, Vol.20 (12), p.2953-2963
Main Authors: Shaw, Joseph R., Li, Na, Nixon, Joanne, Moffat, Karen A., Spyropoulos, Alex C., Schulman, Sam, Douketis, James D.
Format: Article
Language:English
Subjects:
Administration, Oral
Anticoagulants
Anticoagulants - therapeutic use
atrial fibrillation
Blood Coagulation Tests - methods
Coagulation
Dabigatran
factor Xa inhibitors
Humans
Partial Thromboplastin Time
Patients
Prothrombin
Pyrazoles
Pyridones
Rivaroxaban
Surgery
Thrombin
Thromboplastin
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Summary:Background The Perioperative Anticoagulation Use for Surgery Evaluation study prospectively evaluated a prespecified periprocedural interruption strategy of direct oral anticoagulants (DOACs) among patients with atrial fibrillation. Coagulation testing is widely available and frequently requested prior to invasive procedures. Coagulation assays display poor sensitivity to clinically relevant DOAC concentrations. Objectives Determine the utility of routinely available coagulation testing at predicting a DOAC concentration of
ISSN:1538-7933
1538-7836
1538-7836
DOI:10.1111/jth.15901