Trends in the disease burden of congenital heart disease in China over the past three decades

• Published in: Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban 2022-06, Vol.51 (3), p.267-277
• Main Authors: Pan, Feixia, Xu, Weize, Li, Jiabin, Huang, Ziyan, Shu, Qiang
• Format: Article
• Language: English
• Subjects: Child; Child, Preschool; China - epidemiology; Cost of Illness; Heart Defects, Congenital - epidemiology; Humans; Incidence; Infant, Newborn; Quality-Adjusted Life Years
• ISSN: 1008-9292
• DOI: 10.3724/zdxbyxb-2022-0072

To investigate the disease burden of congenital heart disease (CHD) in China from 1990 to 2019. Using the data from Global Burden of Disease (GBD) study 2019, the incidence, age-standardized incidence rates, the mortality, age-standardized mortality rates, disability-adjusted life year (DALY) and age-standardized DALY rates of CHD were calculated. Time trend analysis of disease burden-related indicators was analyzed by Joinpoint regression model. Age-period-cohort model was used to describe age, period, and birth cohort effects in CHD mortality population. The relationship between age-standardized incidence, mortality, DALY rates of congenital heart disease and human development index (HDI) were analyzed by Pearson correlation. From 1990 to 2019, the mean annual percentage change (AAPC) in age-standardized incidence rate, mortality rate and DALY rate of CHD in China were -0.1%(95% : -0.7%-0.4%)、-3.5%(95% : -3.7%--3.2%) and -3.5%(95% : -3.7%--3.2%), respectively. CHD usually occurred in the first year of life. The mean incidence rate at birth was 2497.9/100 000, and the mean incidence rate under 1 year of age was 2626.6/100 000. During the period of 1995-2000, the incidence rate in newborn and