Controlled release and characterisation of photocaged molecules using in situ LED illumination in solution NMR spectroscopy

Photocaging is an attractive strategy to control molecular behaviour, for example, in chemical synthesis, interaction studies or photodynamic therapies. Here, we demonstrate that in situ illumination by the LED NMRtorch approach enables effective and controlled photocage release with simultaneous mo...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2022-10, Vol.58 (85), p.11973-11976
Main Authors: Bramham, Jack E., Zalar, Matja, Golovanov, Alexander P.
Format: Article
Language:English
Subjects:
Chemical synthesis
Controlled release
Illumination
NMR spectroscopy
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Summary:Photocaging is an attractive strategy to control molecular behaviour, for example, in chemical synthesis, interaction studies or photodynamic therapies. Here, we demonstrate that in situ illumination by the LED NMRtorch approach enables effective and controlled photocage release with simultaneous monitoring of subsequent reactions by solution NMR spectroscopy.
ISSN:1359-7345
1364-548X
DOI:10.1039/d2cc04731d