Real-world application of the updated diagnostic criteria for paraneoplastic neurological syndromes

Following recent discoveries, diagnostic criteria for paraneoplastic neurological syndromes (PNS) have been recently updated. However, how the criteria impact PNS diagnosis is still unclear. We retrospectively applied the previously existing 2004 criteria (2004-c) and the updated 2021 diagnostic cri...

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Bibliographic Details
Published in:Journal of neuroimmunology 2022-11, Vol.372, p.577972-577972, Article 577972
Main Authors: Campetella, Lucia, Papi, Claudia, Sabatelli, Eleonora, Marini, Sofia, Iorio, Raffaele
Format: Article
Language:English
Subjects:
Autoimmune diseases
Diagnostic criteria
Humans
Paraneoplastic neurological syndromes
Paraneoplastic Syndromes
Paraneoplastic Syndromes, Nervous System - diagnosis
PNS
Reproducibility of Results
Retrospective Studies
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Summary:Following recent discoveries, diagnostic criteria for paraneoplastic neurological syndromes (PNS) have been recently updated. However, how the criteria impact PNS diagnosis is still unclear. We retrospectively applied the previously existing 2004 criteria (2004-c) and the updated 2021 diagnostic criteria (2021-c) to 74 patients with suspect PNS. The 2021 criteria were highly sensitive (88%) and specific (80%). There was good concordance between the definite PNS group (2004-c) and the definite plus probable PNS group (2021-c). The inter-rater reliability for the 2021-c was excellent. The application of the 2021 criteria improves the diagnosis of patients with PNS. [Display omitted]
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2022.577972