Phenotypic and genotypic antibiotic resistance patterns in Salmonella Typhimurium and its monophasic variant from pigs in southern Spain

The high incidence of human salmonellosis and multi-drug resistant (MDR) strains of Salmonella Typhimurium (ST) is of concern to global public and animal health. Our research, by means of the broth microdilution method, evaluated the Minimum Inhibitory Concentration (MIC) distribution of 12 antimicr...

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Bibliographic Details
Published in:Research in veterinary science 2022-12, Vol.152, p.596-603
Main Authors: Galán-Relaño, Á., Sánchez-Carvajal, J.M., Gómez-Gascón, L., Vera, E., Huerta, B., Cardoso-Toset, F., Gómez-Laguna, J., Astorga, R.J.
Format: Article
Language:English
Subjects:
Ampicillin
Animal health
Animals
Antibiotic resistance
Antibiotics
Antimicrobial agents
Antimicrobial resistance
Antimicrobial resistance determinants
Bioinformatics
By products
Cephalothin
Chloramphenicol
Chloromycetin
Drug resistance
Epidemiology
Food-borne pathogen
Free range systems
Genes
Hogs
Laboratories
Minimum inhibitory concentration
Monophasic Salmonella Typhimurium
Multi-drug resistant
Multidrug resistance
Public health
Salmonella
Salmonella Typhimurium
Salmonellosis
Statistical analysis
Strains (organisms)
Sulfamethoxazole
Trimethoprim
Veterinary medicine
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Summary:The high incidence of human salmonellosis and multi-drug resistant (MDR) strains of Salmonella Typhimurium (ST) is of concern to global public and animal health. Our research, by means of the broth microdilution method, evaluated the Minimum Inhibitory Concentration (MIC) distribution of 12 antimicrobials against a collection of 73 ST and mST and S. typhimurium monophasic variant 4,[5],12:i:- (mST) isolates from slaughtered pigs reared in extensive systems in southern Spain, and also 12 resistance-associated genes or antimicrobial resistance (AMR) determinants using qPCR. Our data revealed that 98.6% of strains were MDR, with resistance to cephalothin/tetracycline/sulfamethoxazole-trimethoprim/ampicillin/chloramphenicol being the most common pattern (55.6%). Regarding AMR determinants, the most significantly (p 
ISSN:0034-5288
1532-2661
DOI:10.1016/j.rvsc.2022.09.028