Influence of COVID‐19 pandemic on molar pregnancy and postmolar gestational trophoblastic neoplasia: An observational study

Objective To assess whether the incidence and aggressiveness of molar pregnancy (MP) and postmolar gestational trophoblastic neoplasia (GTN) changed during the COVID‐19 pandemic. Design Observational study with two separate designs: retrospective multicentre cohort of patients with MP/postmolar GTN...

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Published in:BJOG : an international journal of obstetrics and gynaecology 2023-02, Vol.130 (3), p.292-302
Main Authors: Campos, Vanessa, Paiva, Gabriela, Padron, Lilian, Freitas, Fernanda, Pedrotti, Luana Giongo, Sun, Sue Yazaki, Viggiano, Maurício, Oliveira, Larissa, Rohr, Lucia, Madi, José Mauro, Arrym, Tiago Pedromônico, Oliveira, Priscila, Santos Esteves, Ana Paula Vieira, Junior, Joffre Amim, Filho, Jorge Rezende, Elias, Kevin M., Horowitz, Neil S., Braga, Antônio, Berkowitz, Ross S.
Format: Article
Language:English
Subjects:
Chemotherapy
Chorionic Gonadotropin
COVID-19
COVID-19 - epidemiology
Cross-Sectional Studies
Female
Gestational age
gestational trophoblastic disease
Gestational Trophoblastic Disease - epidemiology
gestational trophoblastic neoplasia
Humans
hydatidiform mole
Hydatidiform Mole - epidemiology
Hydatidiform Mole - therapy
Observational studies
Pandemics
Pregnancy
Questionnaires
Retrospective Studies
Trophoblastic disease
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Summary:Objective To assess whether the incidence and aggressiveness of molar pregnancy (MP) and postmolar gestational trophoblastic neoplasia (GTN) changed during the COVID‐19 pandemic. Design Observational study with two separate designs: retrospective multicentre cohort of patients with MP/postmolar GTN and a cross‐sectional analysis, with application of a questionnaire. Setting Six Brazilian Reference Centres on gestational trophoblastic disease. Population 2662 patients with MP/postmolar GTN treated from March–December/2015–2020 were retrospectively evaluated and 528 of these patients answered a questionnaire. Methods Longitudinal retrospective multicentre study of patients diagnosed with MP/ postmolar GTN at presentation and a cross‐sectional analysis, with application of a questionnaire, exclusive to patients treated during the period of study, to assess living and health conditions during the COVID‐19 pandemic compared with previous years. Main outcome measures The incidence of MP/postmolar GTN. Results Compared with the last 5 pre‐pandemic years, MP/postmolar GTN incidence remained stable during 2020 (COVID‐19 pandemic). Multivariable logistic regression, adjusted for the patient age, showed that during 2020, presentation with MP was more likely to be >10 weeks of gestation (adjusted odds ratio [aOR] 2.50, 95% confidence interval [CI] 1.90–3.29, P 
ISSN:1470-0328
1471-0528
DOI:10.1111/1471-0528.17313