Quality of life, anxiety, depression, and distress in patients with advanced and metastatic lung cancer

• Published in: Palliative & supportive care 2023-08, Vol.21 (4), p.608-615
• Main Authors: Gonzalez-Ling, Ana, Galindo Vázquez, Oscar, Espinoza Bello, Marcos, Robles, Rebeca, Rascón-Gasca, María Luisa, Lara-Mejía, Luis, Heredia, David, Arrieta, Oscar
• Format: Article
• Language: English
• Subjects: Anxiety; Anxiety - psychology; Anxiety Disorders; Cancer therapies; Chemotherapy; Depression - complications; Depression - psychology; Electronic health records; Female; Females; Hospitals; Humans; Immunotherapy; Lung cancer; Lung Neoplasms - complications; Lung Neoplasms - psychology; Medical prognosis; Mental depression; Mental disorders; Middle Aged; Oncology; Patients; Population; Psychologists; Quality of life; Quality of Life - psychology; Software; Well being
• ISSN: 1478-9515; 1478-9523
• DOI: 10.1017/S147895152200116X

Lung cancer (LC) patients have shown a predisposition for developing emotional and physical symptoms, with detrimental effects on the quality of life (QoL). This study evaluates the bidirectional relationship between main psychological disorders and clinical/sociodemographic factors with the QoL. In this observational cross-sectional study, patients with a confirmed LC diagnosis from February 2015 to March 2018 were eligible for this study. Each participant completed screening instruments of anxiety, depression, distress, and QoL assessment. Other relevant clinical data were extracted from electronic health records. Then comparisons, correlations, and logistic regression analyses were performed. Two hundred and four cases were eligible; of them, the median age was 61 (24-84) years, most had clinical stage IV (95%), and most were under first-line therapy (53%). Concerning psychological status, 46% had symptoms of emotional distress, 35% anxiety, and 31% depression. Patients with psychological disorders experienced a worse global QoL than those without psychological impairment ( < 0.001). Increased financial issues and physical symptoms, combined with lower functioning, were also significantly associated with anxiety, depression, and distress. In the multivariate analysis, female sex and emotional distress were positively associated with an increased risk of depression; likewise, female sex, low social functioning, insomnia, and emotional distress were associated with anxiety. Emotional symptoms and QoL had a significant bidirectional effect on this study; this underscores the necessity to identify and treat anxiety, depression, and distress to improve psychological well-being and the QoL in LC patients.