Effects of Combined Treatment with Compounds Affecting Mitochondria on Physiological Parameters in Old Monkey

Correction of mitochondrial function is a promising direction for modulating aging processes. The effect of NAD + (in the form of its precursor nicotinamide mononucleotide, NMN) and antioxidant MitoQ specifically affecting mitochondria was studied on male rhesus monkeys ( Macaca mulatta ). The first...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2022-09, Vol.173 (5), p.651-654
Main Authors: Klots, I. N., Gvozdik, T. E., Shamsutdinova, O. A., Mukhametzyanova, E. I., Keburiya, V. V., Gvaramiya, I. A., Karal-ogly, D. D.
Format: Article
Language:English
Subjects:
Age
Aging
Animals
Biomedical and Life Sciences
Biomedicine
Body temperature
Body weight
Cell Biology
Clinical trials
Drug dosages
Electrocardiogram
Electrocardiography
Hematology
Hemostasis
Internal Medicine
Laboratory Medicine
Mitochondria
Mitochondrial DNA
Monkeys & apes
Niacinamide
Nicotinamide
Pathology
Physiology
Primatology
Values
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Summary:Correction of mitochondrial function is a promising direction for modulating aging processes. The effect of NAD + (in the form of its precursor nicotinamide mononucleotide, NMN) and antioxidant MitoQ specifically affecting mitochondria was studied on male rhesus monkeys ( Macaca mulatta ). The first group of animals initially received only NMN, the second group received only MitoQ, and then both groups received both drugs simultaneously. The above treatment did not lead to changes in the body weight and body temperature, hemostasis, and ECG. The use of MitoQ, but not NMN improved some hematological and biochemical parameters, shifting them to the values of young animals. Changes in these parameters depended on animal age, so the use of MitoQ can only be effective until a certain age. Combined use of the two drugs had no clear advantages over MitoQ alone.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-022-05606-z