Effect of Erythropoietin on Mononuclear Cells of the Bone Marrow and Spleen

We studied the effect of preconditioning of human bone marrow mononuclear cells with erythropoietin on the immunophenotype of immunocompetent cells and paracrine activity of mouse splenocytes. The expression of erythropoietin receptors on immunocompetent human bone marrow cells was shown to change a...

Full description

Saved in:
Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2022-09, Vol.173 (5), p.633-635
Main Authors: Lykov, A. P., Surovtseva, M. A., Bondarenko, N. A., Kim, I. I., Schwartz, Ya. Sh, Poveshchenko, O. V.
Format: Article
Language:English
Subjects:
Apoptosis
B cells
Biomedical and Life Sciences
Biomedicine
Bone marrow
Cardiovascular disease
Cell Biology
Erythropoietin
Erythropoietin receptors
Glucose
Hyperglycemia
Immunocompetence
Immunology
Internal Medicine
Laboratory Medicine
Lactates
Lactic acid
Leukocytes (mononuclear)
Lymphocytes
Lymphocytes B
Monocytes
Oxidases
Oxidative phosphorylation
Oxidative stress
Paracrine signalling
Pathology
Phosphorylation
Spleen
Splenocytes
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We studied the effect of preconditioning of human bone marrow mononuclear cells with erythropoietin on the immunophenotype of immunocompetent cells and paracrine activity of mouse splenocytes. The expression of erythropoietin receptors on immunocompetent human bone marrow cells was shown to change after a short-term (60 min) exposure to erythropoietin. The number of T helpers carrying erythropoietin receptors decreased and the number of T suppressors, B lymphocytes, and monocytes carrying erythropoietin receptors increased. The presence of 30% conditioned medium from human bone marrow mononuclear cells or 33.4 U/ml of erythropoietin reduced apoptosis/necrosis, increased intracellular activity of NADPH-dependent oxidoreductases of splenocytes, and did not affect oxidative phosphorylation (did not enhance lactate production and glucose uptake by cells).
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-022-05602-3