Visible-Light-Induced Metal-Free Decarboxylative Perfluoroalkylation of Aryl Acrylic Acids

Perfluoroalkylation is important for late-stage modification of biologically active molecules. Herein, we report a protocol for visible-light-induced perfluoroalkylation reactions of aryl acrylic acids. These reactions, which use perfluoroalkyl iodides as radical precursors and inexpensive eosin Y a...

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Bibliographic Details
Published in:Organic letters 2022-10, Vol.24 (41), p.7622-7626
Main Authors: Yu, Mo, Niu, Kaikai, Wang, Ziwen, Liu, Yuxiu, Wang, Qingmin
Format: Article
Language:English
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Summary:Perfluoroalkylation is important for late-stage modification of biologically active molecules. Herein, we report a protocol for visible-light-induced perfluoroalkylation reactions of aryl acrylic acids. These reactions, which use perfluoroalkyl iodides as radical precursors and inexpensive eosin Y as a photocatalyst, proceed in a decarboxylative manner. The easy accessibility of perfluoroalkyl iodides and the broad substrate scope, mild conditions, and metal-free catalyst make this protocol applicable for the transformation of inexpensive raw materials to high-value chemicals.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.2c03088