Oncological outcomes of cribriform histology pattern in prostate cancer patients: a systematic review and meta-analysis

Background Changes applied to the Prostate cancer (PCa) histopathology grading, where patients with cribriform patterns (CP) may be categorized as grade group 2 and could hypothetically be surveilled. However, CP has been associated with worse oncological outcomes. The aim of our study is to systema...

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Published in:Prostate cancer and prostatic diseases 2023-12, Vol.26 (4), p.646-654
Main Authors: Russo, Giorgio Ivan, Soeterik, Timo, Puche-Sanz, Ignacio, Broggi, Giuseppe, Lo Giudice, Arturo, De Nunzio, Cosimo, Lombardo, Riccardo, Marra, Giancarlo, Gandaglia, Giorgio
Format: Article
Language:English
Subjects:
631/67/2324
692/699/2768/589/466
Biomedical and Life Sciences
Biomedicine
Cancer Research
Clinical outcomes
Histology
Histopathology
Mens health
Meta-analysis
Mortality
Prostate cancer
Prostatectomy
Quality assessment
Quantitative analysis
Reproductive Medicine
Review Article
Seminal vesicle
Surgical mesh
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Summary:Background Changes applied to the Prostate cancer (PCa) histopathology grading, where patients with cribriform patterns (CP) may be categorized as grade group 2 and could hypothetically be surveilled. However, CP has been associated with worse oncological outcomes. The aim of our study is to systematically review and meta-analyze the available evidence on CP in PCa patients. Methods This analysis was registered on PROSPERO (CRD42022298473). We performed a systematic literature search of PubMed, EMBASE and Scopus using Medical Subject Headings (MeSH) indexes, keyword searches, and publication types until December 2021. The search terms included: “prostate”, “prostate cancer” and “cribriform”. We also searched reference lists of relevant articles. Eligible studies included published journal articles that provided quantitative data on the association between cribriform patterns at radical prostatectomy and the presence of extra-prostatic extension (EPE), seminal vesicle invasion (SVI), positive surgical margins (PSM), biochemical recurrence (BCR) or cancer specific mortality (CSM). Results Overall, 31 studies were included for the quantitative analysis. All articles have been published during a span of 11 years (2011–2022) with a mean month of follow-up of 62.87 months. The mean quality of these studies, assessed with the Newcastle Ottawa Scale was 6.27. We demonstrated that CP was associated with greater risk of EPE (odds ratio [OR] 1.96; P  
ISSN:1365-7852
1476-5608
DOI:10.1038/s41391-022-00600-y