Diurnal rhythms of spontaneous intracranial high-frequency oscillations

• Published in: Seizure (London, England) England), 2022-11, Vol.102, p.105-112
• Main Authors: Petito, Gabrielle T., Housekeeper, Jeremy, Buroker, Jason, Scholle, Craig, Ervin, Brian, Frink, Clayton, Greiner, Hansel M., Skoch, Jesse, Mangano, Francesco T., Dye, Thomas J., Hogenesch, John B., Glauser, Tracy A., Holland, Katherine D., Arya, Ravindra
• Format: Article
• Language: English
• Subjects: Chronobiology; Circadian rhythms; Cosinor model; Drug-resistant epilepsy; Stereo-EEG
• ISSN: 1059-1311; 1532-2688
• DOI: 10.1016/j.seizure.2022.09.019

•Intracranial high-frequency oscillations (HFOs) show a significant diurnal rhythm.•Diurnal rhythm of HFOs is relatively attenuated within the seizure-onset zone (SOZ).•Peak difference in HFO density within/outside SOZ consistently precedes seizures.•Difference in HFO density within/outside SOZ peaks at 1st hour after arousal and ±2 hours around sleep onset. Seizures are known to occur with diurnal and other rhythms. To gain insight into the neurophysiology of periodicity of seizures, we tested the hypothesis that intracranial high-frequency oscillations (HFOs) show diurnal rhythms and sleep-wake cycle variation. We further hypothesized that HFOs have different rhythms within and outside the seizure-onset zone (SOZ). In drug-resistant epilepsy patients undergoing stereotactic-EEG (SEEG) monitoring to localize SOZ, we analyzed the number of 50-200 Hz HFOs/channel/minute (HFO density) through a 24-hour period. The distribution of HFO density during the 24-hour period as a function of the clock time was analyzed with cosinor model, and for non-uniformity with the sleep-wake cycle. HFO density showed a significant diurnal rhythm overall and both within and outside SOZ. This diurnal rhythm of HFO density showed significantly lower amplitude and longer acrophase within SOZ compared to outside SOZ. The peaks of difference in HFO density within and outside SOZ preceded the seizures by approximately 4 hours. The difference in HFO density within and outside SOZ also showed a non-uniform distribution as a function of sleep-wake cycle, with peaks at first hour after arousal and ±2 hours around sleep onset. Our study shows that the diurnal rhythm of intracranial HFOs is more robust outside the SOZ. This suggests cortical tissue within SOZ generates HFOs relatively more uniformly throughout the day with attenuation of expected diurnal rhythm. The difference in HFO density within and outside SOZ also showed non-uniform distribution according to clock times and the sleep-wake cycle, which can be a potential biomarker for preferential times of pathological cortical excitability. A temporal correlation with seizure occurrence further substantiates this hypothesis.