Research on the influence of APOBEC family on the occurrence, diagnosis, and treatment of various tumors

Background Apolipoprotein B mRNA-editing catalytic polypeptide (APOBEC) is a family of highly efficient cytidine deaminase enzymes. APOBECs have been proven to deaminate cytidine on single-stranded DNA or RNA. Inducing the deamination of cytosine on the target gene into uracil, which exerts a variet...

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Bibliographic Details
Published in:Journal of cancer research and clinical oncology 2023, Vol.149 (1), p.357-366
Main Authors: Yang, Jing, Hou, Jiali, Li, Mengxia
Format: Article
Language:English
Subjects:
Adaptive immunity
Apolipoprotein B
Apolipoproteins
Cancer Research
Cytidine deaminase
Cytidine Deaminase - genetics
Cytosine
Deamination
Diagnosis
DNA damage
Drug resistance
Editing
Evolution
Genomes
Hematology
Humans
Immunity, Innate
Innate immunity
Internal Medicine
Liver cancer
Medical research
Medicine
Medicine & Public Health
mRNA
Mutagenesis
Mutation
Neoplasms - diagnosis
Neoplasms - genetics
Neoplasms - therapy
Oncology
Peptides
Physiology
Proteins
Proto-oncogenes
Review
RNA editing
Senescence
Single-stranded DNA
Transcription activation
Tumor suppressor genes
Tumorigenesis
Tumors
Uracil
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Summary:Background Apolipoprotein B mRNA-editing catalytic polypeptide (APOBEC) is a family of highly efficient cytidine deaminase enzymes. APOBECs have been proven to deaminate cytidine on single-stranded DNA or RNA. Inducing the deamination of cytosine on the target gene into uracil, which exerts a variety of physiological functions, plays an important role in innate immunity, adaptive immunity, and antiviral. As the research progresses, APOBECs have been confirmed to be highly expressed in a variety of tumors, causing abnormal mutations in host genes, leading to inactivation of tumor suppressor genes or activation of proto-oncogenes, and their role in tumor development and as diagnostic and treatment markers gradually be found. Conclusion This article will review the mechanism of APOBECs and their impact on tumor occurrence, development, diagnosis, and treatment, and provide a theoretical basis for future tumor treatment.
ISSN:0171-5216
1432-1335
DOI:10.1007/s00432-022-04395-2