Clinical outcomes in individuals hospitalized with SARS-CoV-2 Delta variant (B.1.617.2) who had been vaccinated with Covishield (ChAdOx1) and Covaxin (BBV-152)

• Published in: IJID regions 2022-12, Vol.5, p.104-110
• Main Authors: Munigela, Apoorva, Sowpati, Divya Tej, M, Sasikala, Banu, Sofia, Siva, Archana Bharadwaj, V, Jagadeesh Kumar, Nutalapati, Chandrasekhar, Vishnubhotla, Ravikanth, Kulkarni, Anand, Mukherjee, Payel, Zaveri, Lamuk, Rao, G.V., Tallapaka, Karthik Bharadwaj, Nageshwar Reddy, D.
• Format: Article
• Language: English
• Subjects: Covaxin; COVID-19; Covishield; SARS-CoV-2
• ISSN: 2772-7076; 2772-7076
• DOI: 10.1016/j.ijregi.2022.08.016

•The Delta variant of severe acute respiratory syndrome coronavirus-2 is the predominant variant causing breakthrough infections in India.•Disease severity was significantly lower in vaccinated individuals.•Mortality reduced by >50% in fully vaccinated (two doses) individuals.•Vaccinated individuals had higher antibody levels and lower inflammatory markers.•Vaccinated deceased individuals mounted a minimal antibody response. Covishield (ChAdOx) and Covaxin (BBV-152) are the mainstream vaccines against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) used in India and a few other countries. To assess the clinical outcomes of patients hospitalized with coronavirus disease 2019 (COVID-19) who had been vaccinated with either Covishield or Covaxin. This prospective, single-centre, observational cohort study of 1160 patients hospitalized with COVID-19 was conducted between April and June 2021. Severity of disease at admission and during hospitalization, requirement for intensive care unit (ICU) admission and ventilatory support, inflammatory markers (C-reactive protein, ferritin, lactate dehydrogenase, D-dimer), neutralizing antibody levels and mortality were assessed in vaccinated and unvaccinated patients. More than 90% of patients in this study harboured the Delta variant (Pango lineage B.1.617.2) of SARS-CoV-2. Severity of disease at admission and during hospitalization (3.44% vs 7.51%; P=0.0032) and requirement for ICU admission and ventilatory support (2.83% vs 5.86%; P=0.0154) were significantly lower in vaccinated patients compared with unvaccinated patients. Vaccinated patients also had significantly (P