The association between diabetes mellitus of different durations and risk of pancreatic cancer: an Australian national data-linkage study in women

The bidirectional association between diabetes mellitus (DM) and pancreatic cancer (PC) is established; however, the strength of association between duration of DM and risk of PC needs further investigation. We conducted a case-control study nested within a population-based cohort of Australian wome...

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Bibliographic Details
Published in:Cancer epidemiology 2022-12, Vol.81, p.102266-102266, Article 102266
Main Authors: Ali, Sitwat, Na, Renhua, Tuesley, Karen, Spilsbury, Katrina, Stewart, Louise M., Coory, Michael, Webb, Penelope M., Donovan, Peter, Pearson, Sallie-Anne, Jordan, Susan J., Neale, Rachel E.
Format: Article
Language:English
Subjects:
Bias
Cancer
Comorbidity
Confidence intervals
Datasets
Diabetes
Diabetes mellitus
Diagnosis
Duration
Epidemiology
Estimates
Health risks
Medicare
Mortality
Obesity
Pancreatic cancer
Population studies
Prescriptions
Record-linkage
Risk
Socioeconomics
Statistical analysis
Womens health
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Summary:The bidirectional association between diabetes mellitus (DM) and pancreatic cancer (PC) is established; however, the strength of association between duration of DM and risk of PC needs further investigation. We conducted a case-control study nested within a population-based cohort of Australian women established using record linkage. Women diagnosed with PC from July 2007 to December 2013, were matched to five controls based on age and state of residence. DM was defined according to prescription of anti-diabetic medication from administrative prescription data. We used conditional logistic regression to calculate odds ratios (OR) and 95% confidence intervals (CI), adjusted for area-level socioeconomic status, rurality of residence, weighted comorbidity score, and predicted probability of obesity. The analyses included 7,267 cases and 35,978 controls. The mean age at the time of DM diagnosis was 71 years whereas the mean age at the time of diagnosis of PC was 76 years. A history of DM of any duration was associated with a 2-fold increase in risk of PC (OR=2.12; 95%CI:1.96–2.29) compared to having no history of DM. The risk decreased with increasing duration of DM. The highest risk was in those who had recent-onset DM (OR=8.08; 95%CI:6.88–9.50 for
ISSN:1877-7821
1877-783X
DOI:10.1016/j.canep.2022.102266