Biodegradable Sodium Alginate/Carrageenan/Cellulose Composite Hydrogel Wound Dressings Containing Herbal Extracts for Promoting Blood Coagulation and Wound Healing

• Published in: Macromolecular bioscience 2023-01, Vol.23 (1), p.e2200235-n/a
• Main Authors: Li, Zongyao, Man, Jia, Wang, Xiaojie, Zhang, Yongqi
• Format: Article
• Language: English
• Subjects: Alginates - chemistry; Alginates - pharmacology; Alginic acid; Amaranthus spinosus; Animal models; Animals; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; antibacterial; Antioxidants; Antioxidants - chemistry; Antioxidants - pharmacology; Bandages; Biocompatibility; Biodegradability; Biodegradation; Blood Coagulation; Carrageenan; Carrageenan - pharmacology; Carrageenans; Cellulose; Cellulose - pharmacology; Clotting; Coagulation; Crystalline cellulose; Formulations; hydrogel wound dressings; Hydrogels; Hydrogels - chemistry; Hydrogels - pharmacology; Mechanical properties; Medical dressings; Moisture effects; Plant extracts; promoting blood coagulation; Rubia cordifolia; Sodium; Sodium alginate; Wound Healing; Wound infection
• ISSN: 1616-5187; 1616-5195
• DOI: 10.1002/mabi.202200235

Accelerating the coagulation process and preventing wound infection are major challenges in the wound care process. Therefore, new multifunctional wound dressings with procoagulant, antibacterial, and antioxidant properties have enormous potential for clinical application. In this work, biodegradable hydrogels containing herbal extracts are prepared for wound dressings. First, the active ingredients are extracted from Amaranthus spinosus (A. spinosus) and Rubia cordifolia (R. cordifolia) and added to the hydrogels prepared from microcrystalline cellulose (MCC), carrageenan, and sodium alginate. Then the composite hydrogels are air‐dried to obtain the wound dressings. The wound dressings prepared in this work have good biocompatibility and moisture retention. The mechanical properties of the wound dressings are further improved with the addition of MCC. Besides, the wound dressings have excellent procoagulant, antibacterial, and antioxidant properties due to the presence of R. cordifolia extract. Overall, the most effective group of wound dressings with different ingredient formulations reduces clotting time by 75% and largely inhibits bacterial growth. The wound dressings perform well in the animal wound models to promote wound healing. These results indicate that the hydrogel wound dressings prepared in this work have great potential for medical applications. This research is dedicated to hydrogel wound dressings containing herbal extracts for promoting blood coagulation and wound healing. The wound dressings show excellent procoagulant, antibacterial, and antioxidant properties due to the presence of Rubia cordifolia extract. These results indicate that hydrogel wound dressings containing herbal extract have great potential for medical applications.