Less is More? First Impressions From COSMIC-313

The COSMIC-313 phase 3 randomized controlled trial tested the triplet combination of cabozantinib with nivolumab and ipilimumab in comparison with nivolumab plus ipilimumab control as fist-line systemic therapy in metastatic clear cell renal cell carcinoma. The first results presented at the 2022 Eu...

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Bibliographic Details
Published in:Cancer investigation 2023-01, Vol.41 (1), p.101-106
Main Author: Msaouel, Pavlos
Format: Article
Language:English
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Summary:The COSMIC-313 phase 3 randomized controlled trial tested the triplet combination of cabozantinib with nivolumab and ipilimumab in comparison with nivolumab plus ipilimumab control as fist-line systemic therapy in metastatic clear cell renal cell carcinoma. The first results presented at the 2022 European Society of Medical Oncology Congress are a milestone for the renal cell carcinoma field because they signal the advent of triplet combinations as potential treatment options for our patients. The present commentary highlights some considerations and potential next steps based on these first impressions.
ISSN:0735-7907
1532-4192
DOI:10.1080/07357907.2022.2136681