Association of Interleukin-6 Polymorphisms with Schizophrenia and Depression: A Case-Control Study

Abstract Objective Growing evidence suggests a crossover in genetic susceptibility to schizophrenia and depression. We aimed to investigate the association of the rs1800795 and rs1800796 polymorphisms of the IL-6 gene with schizophrenia and depression in the Han Chinese population, combined with IL-...

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Published in:Laboratory medicine 2023-05, Vol.54 (3), p.250-255
Main Authors: Lu, Danyu, Wang, Minli, Yang, Tongfei, Wang, Jianyou, Lin, Baiquan, Liu, Guoyan, Liang, Qiaoyan
Format: Article
Language:English
Subjects:
Case-Control Studies
Depression - blood
Depression - genetics
Depression, Mental
Disease susceptibility
Enzyme-linked immunosorbent assay
Enzymes
Ethylenediaminetetraacetic acid
Genes
Genetic aspects
Genetic polymorphisms
Genetic Predisposition to Disease
Genotype
Humans
Interleukin-6 - blood
Interleukin-6 - genetics
Interleukins
Polymorphism, Single Nucleotide - genetics
Schizophrenia
Schizophrenia - blood
Schizophrenia - genetics
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Summary:Abstract Objective Growing evidence suggests a crossover in genetic susceptibility to schizophrenia and depression. We aimed to investigate the association of the rs1800795 and rs1800796 polymorphisms of the IL-6 gene with schizophrenia and depression in the Han Chinese population, combined with IL-6 serum levels. Methods Gene sequencing and enzyme-linked immunosorbent assay were performed on 113 subjects with schizophrenia, 114 subjects with depression, and 110 healthy controls. Results Our findings showed that IL-6 concentrations in schizophrenia and depression groups were significantly higher than in the control group. The rs1800796 CC genotype and C allele were significantly associated with depression (P = .012 and P < .05, respectively). The rs1800796 CC and CG genotype was significantly associated with chronic schizophrenia (P = .020 and P = .009, respectively). Regarding the rs1800795 polymorphism, only one case of CG genotype was detected. The remainder were of the GG genotype. Conclusion The IL-6 rs1800796 might serve as a protective factor for depression and schizophrenia in the Han Chinese population.
ISSN:0007-5027
1943-7730
DOI:10.1093/labmed/lmac099