Blue Light-Mediated, Photocatalyst-Free Decarboxylative Alkylation of Heteroaryl Sulfinimines

We report a diastereoselective, photocatalyst-free decarboxylative alkylation of (hetero)­aryl sulfinimines using redox-active esters under blue light. High yields and diastereoselectivities can be achieved under mild conditions, and we demonstrate its utility as a synthetic method, especially for m...

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Bibliographic Details
Published in:Journal of organic chemistry 2022-11, Vol.87 (21), p.14948-14952
Main Authors: Zhou, Zhe, Sales, Zachary S., Pippel, Daniel J., Qian, Michael, Martin, Connor L.
Format: Article
Language:English
Subjects:
Alkylation
Catalysis
Imines
Molecular Structure
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Summary:We report a diastereoselective, photocatalyst-free decarboxylative alkylation of (hetero)­aryl sulfinimines using redox-active esters under blue light. High yields and diastereoselectivities can be achieved under mild conditions, and we demonstrate its utility as a synthetic method, especially for medicinal chemists.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.2c01861