Impact of Bifidobacterium animalis subsp. lactis HN019 probiotic in the prevention of periodontitis associated with immunosuppression

Background This study evaluated the effects of the probiotic Bifidobacterium animalis subsp. lactis HN019 (HN019) in the development of experimental periodontitis (EP) in rats submitted to chemotherapy (5‐fluorouracil [5FU]). Methods Eighty male rats were divided into the following groups: control (...

Full description

Saved in:
Bibliographic Details
Published in:Journal of periodontology (1970) 2023-03, Vol.94 (3), p.389-404
Main Authors: Maia, Luciana Prado, Almeida Silva Levi, Yara Loyanne, Henrique Félix Silva, Pedro, Carla Wons, Luana, Pizzo Pitelli, Livia, Goulart de Castro, Jéssica, da Silva Dólens, Eder, Gregorio, Danielle, Gouveia Straioto, Fabiana, dos Santos Santinoni, Carolina, Casarin, Renato, Ervolino, Edilson, Aparecida Chaves Furlaneto, Flávia, Reis Messora, Michel
Format: Article
Language:English
Subjects:
Animals
antineoplastic agents
Bifidobacterium animalis
Fluorouracil - therapeutic use
Immunosuppression Therapy
Male
periodontitis
Periodontitis - microbiology
probiotics
Probiotics - pharmacology
Probiotics - therapeutic use
Rats
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background This study evaluated the effects of the probiotic Bifidobacterium animalis subsp. lactis HN019 (HN019) in the development of experimental periodontitis (EP) in rats submitted to chemotherapy (5‐fluorouracil [5FU]). Methods Eighty male rats were divided into the following groups: control (C); treated with 5FU (60 mg/kg at day 30 and 40 mg/kg at day 32); treated with probiotic (HN019) (daily, for 44 days, starting at day 0); treatment with 5FU and probiotic (5FU‐HN019); only EP (EP) (ligature placed on lower first molars at day 30, maintained for 14 days); EP and treatment with 5FU (EP‐5FU); EP and treatment with probiotic (EP‐HN019); and EP and treatment with 5FU and probiotic (EP‐5FU‐HN019). Euthanasia occurred at day 44. Morphometric, histomorphometric, microtomographic, immunohistochemical, immunoenzymatic, and gene expressions analyses were performed. The data obtained were statistically analyzed (p 
ISSN:0022-3492
1943-3670
DOI:10.1002/JPER.22-0146