Associations Between Sleep and Metabolic Outcomes in Preadolescent Children

Growing evidence suggests an important role for sleep for the metabolic health of children. We aimed to determine how sleep is related to insulin sensitivity, insulin secretion, beta-cell function, and adiposity (BMI z-scores, body fat %, waist to height ratio) using objectively measured sleep and o...

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Bibliographic Details
Published in:Journal of the Endocrine Society 2022-10, Vol.6 (11), p.bvac137
Main Authors: Alves, Jasmin Marie, Chow, Ting, Nguyen-Rodriguez, Selena, Angelo, Brendan, Defendis, Alexis, Luo, Shan, Smith, Alexandro, Yunker, Alexandra Grace, Xiang, Anny H, Page, Kathleen Alanna
Format: Article
Language:English
Subjects:
Body mass index
Children
Dextrose
Exercise
Glucose
Glucose tolerance tests
Health aspects
Health maintenance organizations
Insulin
Insulin resistance
Mediation
Type 2 diabetes
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Summary:Growing evidence suggests an important role for sleep for the metabolic health of children. We aimed to determine how sleep is related to insulin sensitivity, insulin secretion, beta-cell function, and adiposity (BMI z-scores, body fat %, waist to height ratio) using objectively measured sleep and oral glucose tolerance test (OGTT)-derived measures. Sixty-two children aged 7-11 years, born at Kaiser Permanente Southern California, wore wrist accelerometers for 7 days to objectively measure sleep, completed an OGTT, and had anthropometric measures (height [cm], weight [kg], waist [cm], body fat [%]) collected. Using linear regression, associations between Matsuda insulin sensitivity index (ISI), insulinogenic index (IGI), disposition index (DI), BMI z-score, waist to height ratio, and body fat % with sleep parameters [total sleep time (TST; min), sleep efficiency (SE; %), time in bed (TIB; min), wake after sleep onset (WASO; min), and sleep latency (SL; min)] were assessed. Body fat % was tested as a mediator of the relationship between TST and ISI. Longer TST was associated with better insulin sensitivity (  = 0.02), but not after adjusting for body fat %. Sleep parameters were not associated with IGI or DI. Longer TST was associated with lower % body fat (  = 0.01) and lower waist-to-height-ratios (  = 0.05). Body fat % explained 62% (  = 0.01) of the relationship between TST and ISI. Longer TIB was associated with lower adiposity measures (  
ISSN:2472-1972
2472-1972
DOI:10.1210/jendso/bvac137