Association between genetic polymorphisms in the melatonin receptor type 1 A gene and sleep bruxism

• Published in: Archives of oral biology 2022-12, Vol.144, p.105565-105565, Article 105565
• Main Authors: Gaio, Daniella Cristina, Sebastiani, Aline Monise, do Nascimento Meger, Michelle, Duarte, Joyce, Polmann, Helena, Pauletto, Patrícia, Réus, Jéssica Conti, Souza, Juliana Feltrin de, Souza, André Vieira de, Machado-Souza, Cleber, Maia, Israel Silva, Canto, Graziela De Luca, Brancher, João Armando
• Format: Article
• Language: English
• Subjects: Bruxism; Genetic polymorphisms; Genetics; Sleep bruxism
• ISSN: 0003-9969; 1879-1506
• DOI: 10.1016/j.archoralbio.2022.105565

This study evaluated whether single nucleotide polymorphisms in the melatonin receptor type 1 A gene are associated with sleep bruxism in a Brazilian population. Individuals with suspected sleep-related problems were evaluated using polysomnography, following the recommendations proposed by the American Academy of Sleep Medicine and the Research Diagnostic Criteria for Temporomandibular Disorders. Deoxyribonucleic acid (DNA) samples were collected, and three single nucleotide polymorphisms in the melatonin receptor type 1 A gene (rs13140012, rs6553010, and rs6847693) were selected and genotyped using real-time polymerase chain reaction (RT-PCR). Chi-square and odds ratio tests were used to analyze genotypes and alleles individually, while using the plink software for haplotypes. A confidence interval of 95% was considered, and statistical significance was set at p  0.05). Haplotype genetic analysis also did not reveal any association between single nucleotide polymorphisms and sleep bruxism (p > 0.05). The genetic polymorphisms rs6553010, rs13140012, and rs6847693 were not associated with sleep bruxism in the studied population. •Sleep bruxism likely comes from genetic/neurologic/living environment interactions.•Haplotype analysis did not associate the melatonin gene with sleep bruxism.•Melatonin Receptor Type 1A polymorphismas were not associated with sleep bruxism.