Serum IGF-1 to IGFBP-3 Molar Ratio: A Promising Diagnostic Tool for Growth Hormone Deficiency in Children

Abstract Background The serum insulin-like growth factor-1 (IGF-1)/insulin-like growth factor binding protein-3 (IGFBP-3) ratio has various potential applications in growth hormone-related disorders. This study aimed to investigate the performance of the IGF-1/IGFBP-3 ratio, independently and in com...

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Published in:The journal of clinical endocrinology and metabolism 2023-04, Vol.108 (4), p.986-994
Main Authors: Haj-Ahmad, Laith M, Mahmoud, Muhannad M, Sweis, Nabil W G, Bsisu, Isam, Alghrabli, Ahmad M, Ibrahim, Alaa M, Zayed, Ayman A
Format: Article
Language:English
Subjects:
Child
Children
Cross-Sectional Studies
Diagnosis
Dwarfism, Pituitary
Growth Disorders - diagnosis
Growth Hormone - metabolism
Growth hormones
Human Growth Hormone
Humans
Hypopituitarism
Insulin
Insulin-Like Growth Factor Binding Protein 3
Insulin-like growth factor I
Insulin-Like Growth Factor I - metabolism
Insulin-like growth factors
Medical research
Medicine, Experimental
Protein binding
Somatropin
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Summary:Abstract Background The serum insulin-like growth factor-1 (IGF-1)/insulin-like growth factor binding protein-3 (IGFBP-3) ratio has various potential applications in growth hormone-related disorders. This study aimed to investigate the performance of the IGF-1/IGFBP-3 ratio, independently and in combination with serum IGF-1 and IGFBP-3, in the diagnosis of growth hormone deficiency (GHD) in children with short stature (SS). Methods A 7-year cross-sectional observational study was conducted on 235 children with SS. Participants with known disorders that may affect IGF-1 other than GHD were excluded. Participants were classified into GHD (n = 64) and non-GHD (n = 171) groups. GHD was defined as a slow growth rate (
ISSN:0021-972X
1945-7197
DOI:10.1210/clinem/dgac609